Bayer Aktiengesellschaft

Bayer Pharma Aktiengesellschaft

Karl Collins

Udo Albus

Klemens Lustig

Thomas Ernst Müller

Michael Hahn

Niels Lindner

Martina Delbeck

Doris Gehring

Björn Rosenstein

Moritz Beck-Broichsitter

Janine Nicolai

Carsten Schmeck

Jürgen Klar

Alexey Gromov

Antje Kahnert

Johanna Anlahr

Thomas Müller

Jan Dreher

Andre Philippe Dieskau

Anja Giese

Anna Lena Andreevski

David Engel

Jens Willwacher

Alexander Helmut Michael Ehrmann

Hongkai Dang

Dehe Duan

Jianfei Yang

Denghui Chen

The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, such as compounds of the general formula (I): to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

Diazabicyclic substituted imidazopyrimidines and their use for the treatment of breathing disorders

The present invention covers substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine compounds of general formula (I) as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of cardiovascular and renal diseases, as a sole agent or in combination with other active ingredients.

Substituted 6-(1H-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof

The present application relates to novel imidazopyridinyl- or imidazopyrimidinyl-substituted, bridged 1,4-diazepane derivatives of formula (I), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases, and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for treatment and/or prevention of respiratory disorders including, sleep-related respiratory disorders such as obstructive sleep apnoeas and central sleep apnoeas and snoring. Formula (I) in which the ring Q represents a bridged 1,4-diazepane cycle. 

Substituted bridged diazepane derivatives and use thereof as TASK-1 and TASK-3 inhibitors

The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to their use for preparing medicaments for the treatment and/or prevention of diseases, especially for treatment and/or prevention of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnoea and snoring.

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Düsseldorf, Germany

Karl Collins