Ge Healthcare Bio-sciences Ab

Other

Biacore Ab

Ridgeview Instruments Ab

Nicator Ab

Ridgeview Diagnostics Ab

Kontigo Care Ab

Andersson, Karl

Ridgeview Transportation Kb

Karl Andersson

Christina Wass

Robert Karlsson

Magnus Malmqvist

Knut M Andersson

Johan Arthursson

Peter Borg

Pär Säfsten

Markku H&auml;m&auml;l&auml;inen

H&aring;kan E Roos

Axel G Gustavsson

John Strandgard

Helen Bäckgren

Patrik Berglund

Francis Markey

Lars Gedda

Andrew E Wilkinson

Annika Remaeus

Fredrik Edebratt

Lena Lebel

Andreas ZETTERSTRÖM

Markku HÄMÄLÄINEN

John STRANDGÅRD

Hanna BJÖRKELUND

Anders Alvén

Patrick Berglund

Anna Moberg

Disclosed is a solid support suitable for improving the detection of how different species interact with each other. The solid support has multiple defined areas divided by low dividers, and optionally independent containers divided by high dividers, each container having at least two defined areas. The solid support is typically used in measurements where the total amount of liquid is temporarily reduced during measurement. The solid support extends the possibilities of the measurement system.

Solid support for improved detection of interaction between species

A method of determining kinetic parameters for a reversible molecular interaction between a ligand immobilized to a solid support surface and a binding partner to the ligand in solution, comprises sequentially, without intermediate regeneration or renewal of the immobilized ligand, flowing a plurality of fluid volumes containing different known concentrations of the binding partner over the solid support surface, monitoring the momentary amount of binding partner bound to the solid support surface related to time and solution concentration of binding partner and collecting the binding data, and determining the kinetic parameters by globally fitting a predetermined kinetic model for the interaction between the binding partner and the immobilized ligand to the collected binding data, which model allows for mass transport limitation at the solid support surface. An analytical system for carrying out the method, a computer program, a computer program product and a computer system for performing the method are also disclosed.

Method and system for determination of molecular interaction parameters

A method of analysis or diagnosis of solid objects is based on real-time detection of how predefined probes interact with structures present on or in the solid object combined with the calculation of how the recorded binding curves of said probes are distributed in terms of interaction properties. The interaction properties are input to a classification algorithm which automatically determines statues of the solid object. The method is particularly advantageous for solid biological objects like tissue slices combined with antibody probes, said antibody recognizing receptors known to be over-expressed in disease states on said tissue slice.

Method for the analysis of solid objects

A method of analysis wherein molecular interactions at one or more sensing surface areas are detected and respective response curves representing the progress of each interaction with time are produced, and wherein a resulting set of response curves is subjected to a quality assessment procedure which comprises representing the response curves with one or more quality descriptors, applying a quality classification method to the descriptors to find outliers, and removing the outliers. The invention also relates to an analytical system including means for classifying the response curves with regard to quality, a computer program for performing the classification, and a computer program product containing the program.

Method and system for curve quality control

A device detects interactions between species in liquid and species on a solid support. It includes a solid support (), a mechanism () for temporarily reducing the amount of a liquid to which the support is exposed, a detector () capable of detecting an interaction between species attached to the solid support, and species contained in the liquid. Also described is a method including attaching a first species on a solid support, exposing the first species to a liquid containing a second species, performing a measurement, capable of detecting an interaction between the first and the second species, and a reference measurement. The liquid is temporarily removed during the measurement.

Method and device for the characterization of interactions between different species

The invention relates to a method of characterizing interaction between two species in a liquid environment, wherein a liquid comprising said at least one species is passed as a flow through a measurement system, and wherein the interaction takes place within said measurement system. The method comprises generating a concentration gradient of at least a first one of said species or of at least one other species having an influence on the interaction or on interacted components. The flow of liquid is passed through a sensor device, and a result of interaction between said at least two species is detected. The flow of liquid is intersected at least once with a further liquid before the flow is passed through said sensor, so as to create at least two separated liquid segments having different concentrations of at least one of said species forming the concentration gradient.

Method and apparatus for characterization of interactions

A method and an apparatus for the development of a control process for an instrument are disclosed. The method comprises a first step of selecting one or more commands from a plurality of pre-defined commands in which at least one of the selected one or more commands being a purpose-linked command; and a second step of combining the selected one or more commands to produce the control process. The pre-defined commands have a control part for controlling the operation of the instrument and at least one of the pre-defined commands has a purpose part for controlling the purpose of the command. The apparatus for the development of a control process for an instrument comprises a first memory for storing a plurality of control parameters for individual ones of a plurality of commands, a display device for displaying information relating to the plurality of commands, a selection device for selecting ones of the plurality of commands and a processor for combining selected ones of the plurality of commands for producing the control process.

Method and apparatus for the development of a control process for an instrument

Surface regeneration of affinity biosensors and characterization of biomolecules associated therewith by multivariate technique employing cocktails of regeneration agents to optimize regeneration of biosensor surface and/or characterize biomolecules associated therewith. Kits and stock solutions for use in the context of this invention, as well as associated computer algorithms are also disclosed.

Surface regeneration of biosensors and characterization of biomolecules associated therewith

Wheel camber meter mounting

Method and an arrangement for the preparation of insert bodies for the

The present invention relates to a method for replacing lost tooth substance wherein a model is made from an impression of a prepared tooth or teeth upon which the replacement is to be made. The model serves as a master for transferring the shape of the model to work pieces by means of mechanical processing means.

Method for replacing lost dental substance

Growing community of inventors

Uppsala, Sweden

Karl Andersson