Apoteksvarucentralen Vitrum Ab

Kabivitrum Ab

Kabi Pharmacia Aktiebolag

Karl A Wretlind

Bengt M Ajaxon

Stellan Ljungberg

Ivan Hakansson

Emulsion for parenteral administration

The invention relates to an emulsion for use as an X-ray contrast agent and containing one or more iodinated lipids emulsified in an aqueous phase. The emulsion contains one or more amino acids, fatty acids or their salts, fat-soluble vitamins and/or urea for increasing its stability. Furthermore, the emulsion may contain one or more pharmacologically acceptable oils or fats. By the stability-increasing agent, it has been possible to prepare emulsions of iodinated lipids which can be sterilized in an autoclave and be stored for a long time without the emulsion breaking.

Iodine-containing emulsion

According to the invention, the parenteral administration of water-insoluble pharmacologically active agents is enhanced wherein the agents are administered in the lipoid phase of a carrier emulsion comprising a microemulsion of a finely dispersed lipoid in an aqueous phase. The lipoid preferably has a mean particle size below 1 micron. This makes it possible to administer water-insoluble agents in high concentrations, and thus a lower dose, whereby a rapid onset of the pharmacological effect is accompanied by a markedly reduced incidence of injury to body tissues.

Composition for enhancing the administration of pharmacologically active

According to the method of the invention, the parenteral administration of water-insoluble pharmacologically active agents is enhanced wherein the agents are administered in the lipoid phase of a carrier emulsion comprising a microemulsion of a finely dispersed lipoid in an aqueous phase. The lipoid preferably has a mean particle size below 1 micron. This makes it possible to administer water-insoluble agents in high concentrations, and thus a lower dose, whereby a rapid onset of the pharmacological effect is accompanied by a markedly reduced incidence of injury to body tissues.

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Stockholm, Sweden

Karl A Wretlind