Collagen Corporation

Ramot Ltd.

Karl A Piez

Thomas L Smestad

George H Chu

Bruce B Pharriss

Diana M Hendricks

Hanne Bentz

John M McPherson

Saeid Seyedin

Ranga Nathan

Donald G Wallace

George J Todaro

Rosa Armstrong

Saied Seyedin

Shlomo Weintraub

Danile R Twardzik

Jane E Ranchalis

Processes for the preparation of compositions used in conductive bone repair are disclosed. The compositions contain a mixture consisting essentially of either a calcium phosphate particulate mineral component or particulate hydroxyapatite in admixture with atelopeptide reconstituted fibrillar collagen. The method is comprised of mixing a dispersion of the collagen and mineral, the latter which is present in dry particulate form, followed by molding and drying the composition in a mold to obtain a dried composition.

Calcium phosphate/atelopeptide collagen compositions for bone repair

A composition for use in bone repair, in particular, in only procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.

Xenogeneic collagen/mineral preparations in bone repair

A composition suitable for inductive bone implants is disclosed. The composition comprises a purified form of osteogenic factor in admixture with a carrier having a percentage of mineral carrier. The resulting implants are sufficiently hypoimmunogenic to be effective when implanted in xenogeneic hosts.

Inductive collagen-based bone repair preparations

A process for coating the pores of a mineral matrix with collagen by pumping collagen through the molded matrix is disclosed. The resulting coated matrix can be used as a prosthesis in bone repair.

Method of making molds with xenogeneic collagen/mineral preparations for

Polypeptides called cartilage-inducing factors (CIFs) that are found in bone and have heretofore been identified as having in vitro cartilage-inducing activity. TGF-.beta. activity, and anti-inflammatory activity have now been found to possess potent oncostatic activity. The CIFs showed oncostatic activity on human and animal tumors, including carcinomas, adenocarcinomas, lymphomas, and melanomas.

Method of inhibiting tumor growth sensitive to CIF-.beta.treatment

A composition for use in bone repair, in particular, in onlay procedures, which comprises calcium phosphate mineral particles in admixture with atelopeptide reconstituted fibrillar collagen preparations is disclosed. This composition is non-immunogenic and encourages the fusion of host bone with new bone growth through the implant. Additional processes for curing the implant to improve its compressive strength include heat curing, maturation, and cross-linking.

A method of repairing bone defects by use of suspensions containing purified atelopeptide, reconstituted, fibrillar skin collagen or bone collagen powder or mixtures thereof is disclosed. The suspensions provide matrices for conductive growth of bone into the defect. The skin collagen may also be lyophilized and used in the form of mats.

Methods of bone repair using collagen

A composition which combines autogenic bone marrow with a suspension of purified atelopeptide reconstituted collagen is used to repair bone defects in mammals.

Collagen compositions for bone repair containing autogeneic marrow

A composition suitable for inductive bone implants is disclosed. The composition comprises a purified form of osteogenic factor in admixture with an carrier having a percentage of non-fibrillar collagen. The resulting implants are sufficiently hypo-immunogenic to be effective when implanted in xenogeneic hosts.

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Menlo Park, CA, United States of America

Karl A Piez