Pierre Fabre Medicament

Karine Valeille

Elisabeth Dupont-Passelaigue

Didier Junquero

Samuel Mialhe

Isabelle Leroy

Jean-Pierre Rieu

Yves Rival

Elisabeth Dupont-passelaigue

The present invention relates to compounds having general formula I characterized in that  

Nitrogen heterocycle derivatives, preparation thereof and application thereof in human therapeutics

The present invention concerns compounds of general formula (I) characterized in that (formula 1) wherein, in particular: &#x2014;Rrepresents one or more groups such as: trifluoromethyl, halogen such as F, Cl, &#x2014;when n=m=1, W represents CH then Y represents oxygen, &#x2014;U represents: &#x2022;either &#x2014;(C&#x2550;O)CHNH&#x2014; and is branched at position 4 of pyridazinone, then R2 represents H, &#x2022;or &#x2014;(C&#x2550;O)NH&#x2014; and U is branched at positions (4), (5) or (6) of pyridazinone, then R2 represents H, &#x2014;R3 represents a hydrogen or methyl and the addition salts with pharmaceutically acceptable bases and acids and the different isomers, and their mixtures in any proportion for use as SCD-1 enzyme inhibitors for the treatment of obesity, type-2 diabetes and lipid disorders. 

Derivatives of 2H pyridazin-3-ones, their preparation and their use as SCD-1 inhibitors

The present invention relates to derivatives of general formula I wherein: &#x2014;W represents nitrogen, &#x2014;Rrepresents: &#x2022;a hydrogen or a linear or branched C-Calkyl radical or, &#x2022;a C-Calkyl radical substituted with groups such as trifluoromethyl, nitrile, hydroxy, C-Calcoxy, C-Calkoxyalkoxy, indolyl, thiophenyl, oxothiophenyl, C-CN-alkylcarbamoyl groups or, &#x2022;a phenyl or pyridyl or naphthyl, or thiophenyl group optionally substituted with one or more groups such as halogen atoms, nitro, nitrile, trifluoromethyl, vinyl, methylsulfanyl, linear branched C-Calkyl, linear or branched C-Calkoxy groups, &#x2022;a C2-oxocycloalkyl radical&#x2014;Rrepresents a methyl or heptyl, -m, n are equal to 1, &#x2014;V represents CH, &#x2014;X&#x2014;Y represents &#x2014;N&#x2014; (C&#x2550;O)&#x2014;, &#x2014;CH&#x2014;O&#x2014;, &#x2014;Z represents a phenyl group substituted with one or more trifluoromethyl groups, halogen atoms or linear C-Calkyl groups. 

Derivatives of triazines and uracils, their preparation and their application in human therapeutics

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Palaiseau, France

Karine Valeille