Harvard College

Ucb Biopharma Sprl

Karine Jeannine Madeleine Hervé

Kerry Louise Tyson

Ralph Adams

Carl Brendan Doyle

Gökhan S Hotamisligil

Scott B Widenmaier

Elisabeth Helen Roberts

Adrian Richard Moore

Feyza Engin

Shauna Mhairi Wales

Mehmet F Burak

Karen Inouye

David Paul Humphreys

Daniel John Lightwood

David Edward Ormonde Knight

Diane Marshall

Andrew Charles Payne

Joanne Elizabeth Compson

Graham Craggs

Matthew Jon Timothy Page

Nicola Louise Fisher

Brendon Mackenzie

Matthew Cox

This invention is in the area of improved anti-aP2 antibodies and antigen binding agents, and compositions thereof, which target the lipid chaperone aP2/FABP4 (referred to as 'aP2') for use in treating disorders such as diabetes, obesity, cardiovascular disease, fatty liver disease, and/or cancer, among others. In one aspect, improved treatments for aP2 mediated disorders are disclosed in which serum aP2 is targeted and the biological activity of aP2 is neutralized or modulated using low-binding affinity aP2 monoclonal antibodies, providing lower fasting blood glucose levels, improved systemic glucose metabolism, increased systemic insulin sensitivity, reduced fat mass, reduced liver steatosis, reduced cardiovascular disease and/or a reduced risk of developing cardiovascular disease.

Anti-AP2 antibodies and antigen binding agents to treat metabolic disorders

This present invention describes the derivation and selection of antibodies capable of neutralising the major exotoxins; TcdA and TcdB of. The invention also describes novel neutralisation and antigen binding properties of individual Mabs and mixtures thereof.

Neutralising antibodies to the major exotoxins TCDA and TCDB of

Anti-aP2 antibodies and antigen binding agents to treat metabolic disorders

The present invention relates to an anti-CSF-1R antibody and binding fragments thereof, DNA encoding the same, host cells comprising said DNA and methods of expressing the antibody or binding fragment in a host cell. The present invention also extends to pharmaceutical compositions comprising the antibody or a binding fragment thereof and use of the antibody, binding fragment and compositions comprising the same in treatment.

Antibodies

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Vancouver, Canada

Karine Jeannine Madeleine Hervé