Centre National De La Recherche Scientifique

Université´ D'aix-Marseille

K.u. Leuven Research & Development

Karine Alvarez

Jan Balzarini

Johan Neyts

Jean-Louis Romette

Bruno Canard

Karine Barral

This invention relates to a purine or pyrimidine phosphonate compound of formula (I) or pharmaceutically acceptable salt thereof; wherein B, X, and R-Rare as defined in classes and subclasses herein. These compounds may be used as antiviral precursors. The invention also relates to therapeutic compositions of these compounds and their use for the preparation of a medication for testing and/or preventing a viral infection in a patient. The invention also provides methods for making these compounds. In particular, the invention provides an H-phosphinate precursor intermediate of formula (II) wherein B is a purine or pyrimidine base as defined herein and Ris selected from the group comprising a hydrogen atom, and a methyl, ethyl, hydroxymethyl, hydroxyethyl and Chaloalkyl group.

Nucleotide analogues as precursor molecules for antivirals

Growing community of inventors

Marseilles, France

Karine Alvarez