Beth Israel Deaconess Medical Center, Inc.

Duke University

Los Alamos National Security, LLC

The University of Alabama

Triad National Security, LLC

Los Alamos Security, LLC

U. of Alabama at Birmingham Research Foundation

Karina Yusim

Bette T Korber

William M Fischer

Carla L Kuiken

Barton F Haynes

Beatrice H Hahn

Norman L Letvin

James Theiler

Simon J Perkins

Tanmoy Bhattacharya

Dan H Barouch

Bette T M Korber

Christine Bricault

The invention features immunogenic compositions and vaccines containing an optimized human immunodeficiency virus (HIV) envelope (Env) polypeptide (e.g., a stabilized trimer of optimized HIV Env polypeptides) or a polynucleotide encoding an optimized HIV Env polypeptide and uses thereof. The invention also features methods of treating and/or preventing a HIV infection by administering an immunogenic composition or vaccine of the invention to a subject (e.g., a human).

Signature-based human immunodeficiency virus (HIV) envelope (Env) trimer vaccines and methods of using the same

The disclosure generally relates to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods of using same.

Nucleic acids encoding mosaic HIV-1 gag proteins

The present invention relates to mosaic HIV-1 group M Gag sequences and to a composition comprising same.

Human immunodeficiency virus type 1 clade M mosaic gag polypeptides

The invention relates to immunogenic compositions useful as HCV vaccines. Provided are HCV mosaic polypeptide and nucleic acid compositions which provide higher levels of T-cell epitope coverage while minimizing the occurrence of unnatural and rare epitopes compared to natural HCV polypeptides and consensus HCV sequences.

Mosaic protein and nucleic acid vaccines against hepatitis C virus

The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.

Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins

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Los Alamos, NM, United States of America

Karina Yusim