Knoll Aktiengesellschaft

Fresenius Kabi Austria Gmbh

Karin Schaupp

Klaus Sommermeyer

Stanley Stewart Davis

Josef Polzer

Clive Washington

Norbert Feichtinger

Udo Eggenreich

Eckhard Nagel

Andreas Meyer Zu Vilsendorf

Kurt Lanthaler

Gerald Hofer

Johannes Kerbl

Anneliese Wurm

The invention relates to an oil-in-water emulsion comprising, as an active ingredient, &agr;-tocopherol or the stereoisomers thereof and comprising, as an emulsifier, phospholipids. The inventive emulsion is used in order to attain a protective action against damages to human organs resulting from peroxidation. The emulsion contains a &agr;-tocopherol content, with regard to action, of 1.48 g/l to 30 g/l RRR-g(a)-tocopherol, 0-25 g/l of an oil which is compatible with I.V. administration, and 0.25 g/l to 3 g/l of a phospholipid. The emulsion is preferably administered as an infusion and is especially used to reduce damages resulting from peroxidation due to ischemia and /or reperfusion and, among other things, during an organ transplantation.

Oil-in-water emulsion for protecting human organs against peroxidation

A stable active substance emulsion of the oil-in-water type with a phospholipid as emulsifier is described, where the active substance dissolved in the lipid phase has one or more basic groups, is hydrophobic and oil-soluble, and has a pKa of at least 7.5, the aqueous phase is set at an acid pH, and the disperse phase gives a positive zeta potential of at least +15, but preferably +30, mV after dilution of the emulsion ready for administration to a fat content of 0.08% by weight.

Stable emulsion suitable for pharmaceutical administration, the

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Graz, Austria

Karin Schaupp