Intervacc Ab

Biostapro Ab

Guss, Bengt

Flock, Jan-ingmar

Bergman, Rune

Flock, Margareta

Janzon, Kenneth

Jacobsson, Karin

Frykberg, Lars

Karin Jacobsson

Lars Frykberg

Bengt Guss

Jan-Ingmar Flock

Margareta Flock

Kenneth Janzon

Rune Bergman

The present invention is concerned with an antigenic composition comprising at least one antigen that comprises at least one antigenic epitope or antigenic determinant derived from a protein present in one or both ofsubsp.and subsp.and use thereof for immunization of non-human mammals againstsubsp.and/or subsp.. The present invention also discloses a vaccine composition comprising the aforesaid antigenic composition as immunizing component. The antigens used are EAG, FNZ, SFS, SEC and ScLC.

[object Object]

A recombinant DNA molecule coding for a protein expressed by a bacterium, comprising the nucleotide sequence SEQ ID NO:1 or a homologous sequence, or a partial or homologous sequence of SEQ ID NO:1 coding for a polypeptide fragment comprising at least 15 amino acid residues, is described. Further, a protein expressed by such a bacterium or a polypeptide fragment comprising at least 15 amino acid residues, comprising the amino acid sequence SEQ ID NO:2 binds IgG and apolipoprotein H. Examples of the polypeptide fragments comprise the SEQ ID NO:3 through 6. These proteins and polypeptide fragments may be coupled to an inert carrier or matrix. Vectors comprising such a DNA molecule or the corresponding RNA molecule, and antibodies specifically binding to a polypeptide having an amino acid sequence of SEQ ID NO:4 or SEQ ID NO:6, are also disclosed. The DNA or RNA molecules, the vectors and the antibodies mentioned may all be used in different types of vaccines against Staphylococcal infections. Moreover, a method of isolating and/or purifying apolipoprotein H from a liquid medium, especially from serum, is described.

IgG-binding protein from Staphylococcus and nucleotide sequence encoding this protein

Growing community of inventors

Storvreta, Sweden

Karin Jacobsson