Brigham Young University

Other

Karin E Markides

Milton L Lee

Jerald S Bradshaw

Bryon J Tarbet

Bryant E Rossiter

Paul B Farnsworth

Deborah F Johnson

Ronald J Skelton Jr

Frank J Yang

Brian A Jones

Chiral copolymers containing chiral molecular grooves or cavities and oligosiloxane spacers are disclosed. The chiral portion of the copolymer is an enantiomerically enriched organic grouping, having physical properties attributed to uniform and stereochemically possible molecular grooves or cavities, which is chemically and thermally stable to gas, liquid or supercritical s fluid chromatographic conditions and is configured such that one enantiomer of an enantiomeric mixture will be better able to preferentially enter such groove or cavity and interact more strongly than other enantiomers in said mixture. The chiral grouping will contain one Or more combinations of organic moieties selected from the group consisting of methylene, phenylene, naphthylene, biphenylene, binaphthylene, a cyclodextrin and cycloalkylydene and substituted derivatives thereof and also includes non-metal atoms and functional groups which act as linking agents for the organic chiral cavity-containing moieties which are selected from the group consisting of ethers, thioethers, amines, carbonyls, amides, esters, sulfoxides, sulfonates, thioamides, thioesters, ureas, thioureas, carbamates, thiocarbamates, phosphines and phosphine oxides. The use of such polymers as chiral stationary phases in analytical and preparative gas, supercritical fluid and liquid chromatographic separations, and particularly for analysis of enantiomeric and other stereoisomeric mixtures of various substances is shown.

Chiral copolymers with oligosiloxane spacers

Oligoethylene oxide-substituted aryl and aralkyl alkenes, oligoethylene oxide-substituted aryl and aralkyl alkoxy silanes and polysiloxane polymers containing oligoethylene oxide-substituted aryl and aralkyl sidechains and methods for their preparation are disclosed. The oligoethylene oxide-substituted aryl and aralkyl alkenes are used to prepare the oligoethylene oxide substituted polysiloxane polymers which are useful as stationary phase coatings in gas-liquid chromatography and supercritical fluid chromatography in the separation of various closely related chemical substances such as homologs and isomers. The oligoethylene oxide-substituted aryl and aralkyl alkoxy silanes are reactive towards silica particles for use as packing in liquid chromatography columns.

Novel oligoethylene oxide-containing alkenes, alkoxysilanes, and

Chiral arylcarboxamide-containing alkenes and alkoxysilanes and polysiloxane polymers containing chiral arylcarboxamide-substituted side chains and methods for their preparation are disclosed. The chiral arylcarboxamide-containing alkenes are used to prepare the chiral arylcarboxamide-containing polysiloxane polymers which are useful as stationary phase coatings in gas-liquid and supercritical fluid chromatography in the separation and analysis of enantiomeric and other stereoisomeric mixtures of various substances. The chiral arylcarboxamide containing alkoxysilanes are reactive towards silica particles for use as packing in liquid chromatography columns.

Chromatographic arylcarboxamide polysiloxanes

The present invention relates to novel liquid crystalline compounds having the following formula: ##STR1## In the above formula, a is 1 or 2, or R.sub.1 and R.sub.2 may be virtually any chemical groups which will maintain the liquid crystalline properties of the resultant compound. The novel compounds of the present invention contain a biphenylcarboxylate ester moiety so as to define a new class of liquid crystalline compounds. The present invention further includes polymers made from the novel liquid crystalline compounds by attaching the compounds to a polymer backbone such as a polysiloxane backbone. Additionally, the present invention also contemplates methods for using such polymers as stationary phases in the chromatographic analysis of various chemical compounds, such as polycyclic aromatic hydrocarbons (PAH).

Novel liquid crystalline compounds and polymers

A method and apparatus for element specific detection in chromatogragphic eluents. The apparatus is comprised of a radio frequency discharge between electrodes in helium, and utilizes a low-resolution plasma emission spectrometer to monitor selected spectral emissions produced when the helium discharge decomposes and excites the atomic constituents in chromatographic column effluents. The spectrometer is tuned to an atomic emission line in the near-infrared portion of the spectrum, and the emission intensity from the discharge region of a selected line is used to monitor the concentration of the element producing that line. Acceptable detector sensitivity is achieved by the use of a high-throughput optical system. Selectivity is achieved by a combination of correct line selection, plasma and carrier gas purification, and plasma gas doping.

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Springville, UT, United States of America

Karin E Markides