Verovaccines Gmbh

Martin-Luther-Universitaet Halle-Wittenberg

Martin-Luther-Universität Halle-Wittenberg

Karin Breunig

Sven-Erik Behrens

Hans Caspar Hührlimann

Mandy Gebauer

Martina Behrens

The invention relates to recombinant() yeasts which are capable of the highly efficient expression of one or more foreign proteins and are suitable for use as a vaccine for generating a protective immune response against pathogens. The invention provides in particularstrains for the targeted cloning of foreign antigen-coding nucleic acids into the yeast genome of thestrain, which is characterized in that thestrain has integrated expression cassettes for foreign antigens as an alternative or in addition to the KILAC4 locus on the KIURA3-20 locus (KLLA0E22771g) and/or on the KIMET5-1 locus (KLLA0B03938g). The invention further relates to integrative expression vectors and to methods for producing thestrains of the invention as well as to the use thereof as vaccines.

Optimized host/vector system for producing protective mono- and multivalent subunit vaccines on the basis of the yeast

The invention relates to recombinant yeasts of thespecies for the production of a humoral immune response against defined antigens, to the production of said yeasts, and to the use thereof for protective vaccination against pathogens and malignant cells containing said antigens.

Vaccination by means of recombinant yeast by producing a protective humoral immune response against defined antigens

Recombinant yeast cells are produced which are used for vaccination, among other uses for the oral vaccination by feeding.

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Halle/Saale, Germany

Karin Breunig