Tetec Tissue Engineering Technologies Ag

Nmi Naturwissenschaftliches Und Medizinisches Institut an Der Universitaet Tuebingen

Tetec Tissue Engineening Technologies Ag

Nmi Naturwissenschaftliches Und Medizinisches Institut an Der Universitat Tubingen

Karin Benz

Christoph Gaissmaier

Jürgen Mollenhauer

Helmut Wurst

Juergen Mollenhauer

Nils Clausen

Jochen Hecky

Reinout Stoop

Christian Freudigmann

Barbara Platz

Reinout Stoop Stoop

A cell-free combination for use in the controlled, especially decelerated or retarded, release of active ingredient and/or in the production of a formulation in hydrogel form, especially depot formulation in hydrogel form, and/or as a formulation in hydrogel form, especially depot formulation in hydrogel form, and/or for the coating of a medical product, especially implant, preferably with a formulation in hydrogel form, especially depot formulation in hydrogel form, wherein the cell-free combination comprises a first component and a second component, the first component comprising crosslinkable albumin and the second component comprising a crosslinking agent for the albumin. Additionally, a hydrogel-forming material or hydrogel, to a kit or multicomponent system, to a medical product or a pharmaceutical formulation, to a discharge device, and to uses of the cell-free combination and of the hydrogel-forming material or hydrogel.

Cell-free combination, hydrogel-like material or hydrogel and use of same

A method for the in vitro detection of cartilage tissue and/or for the in vitro determination of the purity of cartilage tissue includes: a) treating a tissue sample with a protease and b) testing the protease-treated tissue sample for the presence of protease-resistant fragments of type II collagen and/or type I collagen. Methods can be carried out for preparing a cartilage cell culture, and for preparing a cartilage cell-loaded implant. Protease-resistant fragments of type II collagen and/or type I collagen can be used for the in vitro detection of cartilage tissue and/or for the in vitro determination of the purity of cartilage tissue. A kit can be used for carrying out the methods.

Identity and purity of tissue biopsies

The invention relates to an injectable biocompatible composition based on a polymeric support as well as to a method for producing it, which composition which comprises at least one hydrophilic polymer, wherein the polymer is polymerizable in situ to form a gel, and wherein the hydrophilic polymer is crosslinkable serum albumin or crosslinkable serum protein. The composition can be used in the restoration, the reconstruction, and/or the replacement of tissues and/or organs, or as a drug release implant in mammals. The composition is particularly suitable for treating cartilage disorders of a diseased or injured articular site in a mammal.

Injectable biocompatible composition

An in vitro method of prognostically assessing tissue regeneration capacity and/or cellular potency and/or the prospects of success of an implantation and/or transplantation, wherein the transcriptome and/or the gene expression of cells, the gene expression originating from the transcriptome, are analyzed.

In vitro method of predictive assessment of the prospects of success of an implant and/or transplant

Growing community of inventors

Goeppingen, Germany

Karin Benz