General Electric Company

Centre for Probe Development and Commercialization

Karin Ann Stephenson

Tao Wu

John Fitzmaurice Valliant

Bruce Fletcher Johnson

Michael James Rishel

Randall Lee Carter

Eric Steven Burak

Ryan Wayne Simms

Alla Darwish

John Richard Forbes

Meiduo Hu

Yang Yang

Joel Adamson Drewry

Neil Grant Cockburn

Anup Sood

Mark Christopher Patrick Darey

Mark Christopher Darey

The present invention relates to conjugates including a residualizing linker, methods for their production, and uses thereof.

Residualizing linkers and uses thereof

An embodiment of the invention comprises method of imaging a target site comprising administrating ligand of Formula I complexed toTc wherein Rand Rare independently an alkyl or cycloalkyl; Ris and alkyl; X is CO or SO; Y is (CH2), CH, (OCHCH)(NHCHCH)and (OCHCHCH), or a combination thereof; Z is linker group capable of conjugating to a vector; and n is an integer between 0 and 10.

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The present teachings provide methods that enable the preparation and purification of radioiodinated vectors without the need for HPLC purification, as well as novel precursors which include biotin-like substituents useful in such methods.

Biotin stannane for HPLC-free radioiodination

Growing community of inventors

Burlington, Canada

Karin Ann Stephenson