University of Colorado

University of Pittsburgh

Trustees of the Colorado School of Mines

Karin A Payne

Robert R McLeod

Johnny Huard

Ronald Jankowski

Thomas Payne

Melissa D Krebs

Stephanie Bryant

Virginia Ferguson

Arvydas Usas

Nancy Hadley-Miller

The present invention relates to the unexpected discovery of compositions and methods for the treatment of growth plate defects. In certain embodiments, the methods prevent the growth of 'bony bars' at the site of growth plate injury, thereby preventing growth arrest and/or deformity. In certain embodiments, the compositions comprise hydrogels comprising at least one biological factor capable of preventing bony bar formation.

Hydrogel drug delivery systems for the treatment of pediatric growth plate injuries

The present invention relates to the unexpected discovery of 3D printed biomimetics of growth plate cartilage and methods using the same for the treatment of growth plate defects. In certain embodiments, the methods prevent the growth of bony bars at the site of growth plate injury, thereby preventing growth arrest and/or deformity.

Biodegradable biomimetics of growth plate cartilage for the treatment of physeal injuries

The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.

Bone augmentation utilizing muscle-derived progenitor compositions in biocompatible matrix, and treatments thereof

Growing community of inventors

Denver, CO, United States of America

Karin A Payne