National Institute of Health and Medical Research

Université´ D'aix-Marseille

Centre National De La Recherche Scientifique-Cnrs

Assistance Publique Hopitaux De Marseille

Association Francaise Contre Les Myopathies

Inserm

Progelife

Karim Harhouri

Françoise Dignat-George

Nathalie Bardin

Marcel Blot-Chabaud

Benjamin Guillet

Pierre Cau

Sophie Perrin

Françoise Dignat-george

Martine Simonelig

Annachiara De Sandre-Giovannoli

Aymeric Chartier

Francoise Dignat-George

Nicolas Lévy

The present invention relates to compositions and methods for modulating angiogenesis in vivo, ex vivo or in vitro. More particularly, the invention relates to a soluble CD146 protein usable in the context of human therapy, as well as to corresponding antibodies. Particular forms of CD146, herein described, may be used to mobilize, in vivo or ex vivo, both mature and immature endothelial cells, as well as to increase their influence on angiogenesis. The invention also relates to compositions comprising such compounds, particularly pharmaceutical or diagnostic compositions, including kits and the like, as well as methods of therapy or diagnosis using said compounds, compositions and cells.

Human soluble CD146, preparation and uses thereof

The present invention relates to compositions and methods for modulating angiogenesis in vivo, ex vivo or in vitro. More particularly, the invention relates to a soluble CD 146 protein usable in the context of human therapy, as well as to corresponding antibodies. Particular forms of CD 146, herein described, may be used to mobilize, in vivo or ex vivo, both mature and immature endothelial cells, as well as to increase their influence on angiogenesis. The invention also relates to compositions comprising such compounds, particularly pharmaceutical or diagnostic compositions, including kits and the like, as well as methods of therapy or diagnosis using said compounds, compositions and cells.

Growing community of inventors

Marseilles, France

Karim Harhouri