Second Genome, Inc.

Genevive, Inc.

Karim Dabbagh

Andrew Wonhee Han

Todd Zachary DeSantis

Tarunmeet Gujral

Andrew Whitman Goodyear

Toshihiko Takeuchi

Ye Jin

Andrew W Goodyear

Stefanie Banas

Michi Izumi Willcoxon

Bernat Baeza Raja

Todd Zachary Desantis

Mitsuko Lynn Yamamoto

Shoko Kawana

Helena Kiefel

Kareem L Graham

Yuliya Katlinskaya

Sunit Jain

The disclosure related to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.

Proteins for the treatment of epithelial barrier function disorders

The disclosure relates to therapeutic proteins and pharmaceutical compositions comprising said proteins, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic proteins are useful for treating human gastrointestinal inflammatory diseases and gastrointestinal conditions associated with decreased epithelial cell barrier function or integrity. Further, the disclosed therapeutic proteins are useful for treating human inflammatory bowel disease, including inter alia, Crohn's disease and ulcerative colitis.

The disclosure provides therapeutic peptides and pharmaceutical compositions comprising the peptides, which have utility in treating various human diseases. In particular aspects, the disclosed therapeutic peptides are useful as immunotherapeutics for modulating regulatory and effector molecules of the mammalian immune system to mitigate disease.

Microbially derived peptides and proteins for immunotherapy

The disclosure relates to live biotherapeutic products, probiotics, pharmaceutical compositions comprising said probiotics, and methods of using them to treat various human diseases. In some aspects, the disclosure provides such compositions comprising strains of the bacteriumand their uses in treating metabolic-related diseases or disorder.

as a biotherapeutic

Growing community of inventors

South San Francisco, CA, United States of America

Karim Dabbagh