Instituto De Salud Carlos Iii

Fundacion Publica Andaluza Progreso Y Salud

Karim Benabdellah

Pilar Muñoz Fernández

Alejandra Gutierrez Guerrero

Francisco Martín Molina

Marién Cobo Pulido

The present invention solves the problem of providing more efficient barrier insulators to avoid vector silencing and to increase expression in the setting of gene transfer vectors, more particularly in the setting of gene transfer retroviral vectors. In this sense, the authors of the present invention have developed an improved insulator element, namely element IS2, which comprises the following combination of nucleic acid molecules, namely nucleic acid molecule HS4-650 bp as shown in SEQ ID No 2 and a synthetic S/MAR nucleic acid molecule containing 5 M/SARs recognition signatures (MRS) as shown in SEQ ID no 1.

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Seville, Spain

Karim Benabdellah