Orion Corporation

Orion-Yhtyma Oy

Kari Vahervuo

Marja Partanen

Mervi Niskanen

Sari Kallioinen

Marja Laaksonen

Marja Ritala

Lasse Kervinen

Jarmo Lintulaakso

Matti Virkki

Esko Veikko Marttila

Jaakko A Uotila

Ilkka Larma

An oral solid fixed dose composition comprising pharmacologically effective amounts of entacapone, levodopa, and carbidopa, or pharmaceutically acceptable salts or hydrates thereof, and comprising at least one pharmaceutically acceptable excipient. The composition can be used, e.g., for the treatment of Parkinson's disease.

Pharmaceutical composition comprising entracapone, levodopa, and carbidopa

The present invention relates to an oral compacted composition comprising entacapone, nitecapone, or a pharmaceutically acceptable salt thereof and croscarmellose sodium. The composition is premised on the discovery that croscarmellose sodium increases the release rate of entacapone or nitecapone from an oral compacted composition. Preferably the amount of croscarmellose sodium in the composition is at least 6% by weight, preferably from about 8% to about 16% by weight, especially from about 10% to about 14% by weight.

Oral compacted composition comprising catechol derivatives

Pharmaceutical composition comprising entacapone, levodopa, and carbidopa

The invention relates to a new composition for use on a pharmaceutical granule. The composition is three-layered, comprising as the innermost layer a substantially pure fat, as the middle layer a mixture of fat and polymer, and as the outermost layer again a substantially pure fat. The composition according to the invention produces a preparation which is tasteless, especially when administered in the form of a powder or a mixture, even if the phrmaceutical to be dosed has a bad taste. Also, the preparation keeps well in mixture, and it enables a pharmaceutical to be transported past the stomach for release/absorption at the beginning of the small intestine.

Composition for the oral administration of pharmaceuticals

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Espoo, Finland

Kari Vahervuo