Calcimedica, Inc.

Elitra Pharmaceuticals Inc.

Kari Lynn Ohlsen

Gonul Velicelebi

Kenneth Stauderman

Jack Roos

Paul J Digregorio

Judith W Zyskind

R Allyn Forsyth

John D Trawick

Jamie M Froelich

Robert T Yamamoto

H Howard Xu

Grant J Carr

Methods are provided for identifying agents that modulate intracellular calcium. Also provided are methods of modulating calcium within cells and methods of identifying proteins involved in modulating intracellular calcium.

Methods of modulating and identifying agents that modulate intracellular calcium

Composition comprising a cell comprising a STIM1 protein and an agent that modulates intracellular calcium and methods of use

The sequences of nucleic acids encoding proteins required for proliferation are disclosed. The nucleic acids can be used to express proteins or portions thereof, to obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous genes that are required for proliferation in microorganisms other than The nucleic acids can also be used to design expression vectors and secretion vectors. The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms as well as to screen for antimicrobial agents.

Genes identified as required for proliferation in Escherichia coli

The sequences of nucleic acids encoding proteins required for proliferation are disclosed. The nucleic acids can be used to express proteins or portions thereof, to obtain antibodies capable of specifically binding to the expressed proteins, and to use those expressed proteins as a screen to isolate candidate molecules for rational drug discovery programs. The nucleic acids can also be used to screen for homologous genes that are required for proliferation in microorganisms other than . The nucleic acids can also be used to design expression vectors and secretion vectors. The nucleic acids of the present invention can also be used in various assay systems to screen for proliferation required genes in other organisms as well as to screen for antimicrobial agents.

Genes essential for microbial proliferation and antisense thereto

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San Diego, CA, United States of America

Kari Lynn Ohlsen