Millipore Corporation

Kari A Backes

Stephen J Dzengeleski

Gregory S Straeffer

Kevin Rautio

Curtis H Nauseda

A serial-flow filtration device is provided with pressure-activated pressure-breachable seal or a pressure-activated gate for by-passing at least one of its constituent layer (or layers) of filtration material. The filtration device comprises a housing, a fluid inlet, a fluid outlet, and at least an upper and a rearmost filter layer. The upper filter layer divides the interior of the housing into an upstream zone and a downstream zone, with the rearmost filter layer residing in the downstream zone. The fluid inlet enables the introduction of fluid into said upstream zone. The fluid outlet enables releases of the fluid from said downstream zone. The upper filter layer, but not the rearmost filter layer, has integrated thereinto a pressure-activated pressure-breachable seal or a pressure-activated gate capable of allowing substantially non-selective passage of fluid from the upstream zone into the downstream zone upon the attainment of a predetermined pressure differential across said upper filter layer.

Filtration device with a pressure-activated means for bypassing serial filter layers

The present invention comprises a filter housing having two or more layers of filters. Each layer is preferably spaced apart from each other so as to provide a chamber or gap between them. A port or vent is located within the chamber or gap between the two layers to provide an intermediate path for gas or liquid to flow through one layer of filter or membrane and out the vent or port for integrity testing.

Integrity testable multilayered filter device

A serial-flow filtration device includes a pressure-activated gate for by-passing at least one of its constituent layer (or layers) of filtration material. The filtration device includes a housing, a fluid inlet, a fluid outlet, and at least an upper and a rearmost filter layer. The upper filter layer divides the interior of the housing into an upstream zone and a downstream zone, with the rearmost filter layer residing in the downstream zone. The fluid inlet enables the introduction of fluid into the upstream zone. The fluid outlet enables releases of the fluid from the downstream zone. The upper filter layer, but not the rearmost filter layer, has integrated thereinto a pressure-activated gate capable of allowing substantially non-selective passage of fluid from the upstream zone into the downstream zone upon the attainment of a predetermined pressure differential across upper filter layer.

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Bedford, MA, United States of America

Kari A Backes