Lonza Ag

Lonza Inc.

Other

Karen T Robins

Thomas Zimmermann

Walter Brieden

Uwe Bornscheuer

Andrew Brian Naughton

Nicholas Shaw

Andreas Tinschert

Matthias Höhne

Thomas Gilligan

Uwe Scheuer

Matthias Hoehne

Sebastian Schaetzle

Elisabeth Bohlen

Olwen M Birch

The present invention relates to the production of optically pure secondary amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.

Process for the preparation of optically active chiral amines

The present invention relates to the production of optically active amines, which can be used as intermediate products in a synthesis of for instance pharmaceutical products.

Process for preparation of optically active N-protected 3-aminopyrrolidine or optically active N-protected 3-aminopiperidine and the corresponding ketones by optical resolution of the racemic amine mixtures employing a bacterial omega-transaminase

The present invention relates to processes for the screening, preparation and characterization of (R)-selective &#x3c9;-transaminases, to transaminases obtained thereby and their uses in various transamination processes.

Process for the identification and preparation of a (R)-specific omega-transaminase

The present invention relates to a novel process for the preparation of (S)&#x2014; or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid and to novel microorganisms capable of utilizing the propionamide of the formula in the form of the racemate or of its optically active isomers as the sole nitrogen source.

Process for the preparation of (S)- or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid

The present invention relates to a novel process for the preparation of (S)- or (R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid and to novel microorganisms capable of utilizing the propionamide of the formula in the form of the racemate or of its optically active isomers as the sole nitrogen source.

Process for the preparation of (S) - or (R) -3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid

Described are new micro-organisms and a new enzyme capable of using as sole source of nitrogen the propionic acid amide of formula (VI), in racemate form or as optically active isomers. Described also is a method of preparing (S)- or (R)-3,3,2-trifluoro-2-hydroxy-2-methylpropionic acid of formulas (I) and (II) starting from trifluoroaceto-acetic ester. The first three process steps are chemical, the fourth process step microbiological.

Method of preparing (S)- or (R) -3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid

A genetic engineering process for the production of S-(+)-2,2-dimethylcyclopropanecarboxamide. For this purpose, a new DNA is isolated from a microorganism that codes for a stereospecific hydrolase. This DNA is then ligated in an expression vector, and a hybrid plasmid results, which is transformed into microorganisms. These microorganisms are then able to biotransform the R-(-) isomer in racemic R,S-(.+-.)-2,2-dimethylcyclopropanecarboxamide into R-(-)-2,2-dimethylcyclopropanecarboxylic acid, and optionally active S-(+)-2,2-dimethylcyclopropanecarboxamide is obtained.

Genetic engineering process for the production of

A microbiological process for the production of S-(+)-2,2-dimethylcyclopropanecarboxamide, starting from R,S-(.+-.)-2,2-dimethylcyclopropanecarboxamide. For this process, new microorganisms are selected and isolated, which are capable of biotransforming R-(-)-2,2-dimethylcyclopropanecarboxamide in racemic 2,2-dimethylcyclopropanecarboxamide to R-(-)-2,2- dimethylcyclopropanecarboxylic acid. The process can then be performed either with the microorganisms or with the cell-free enzymes from the microorganisms.

Bacteria capable of stereospecifically hydrolyzing

A microbiological process for the production of S-(+)-2,2-dimethylcyclopropanecarboxamide, starting from R,S-(.+-.)-2,2-dimethylcyclopropanecarboxamide. For this process, new microorganisms are selected and isolated, which are capable of biotransforming R-(-)-2,2-dimethylcyclopropanecarboxamide in racemic 2,2-dimethylcyclopropanecarboxamide to R-(-)-2,2-dimethylcyclopropanecarboxylic acid. The process can then be performed either with the microorganisms or with the cell-free enzymes from the microorganisms.

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Visp, Switzerland

Karen T Robins