Pharmacia & Upjohn Company

Pfizer Corporation

Smithkline Beecham Corporation

Karen Rene Romines

Joseph Walter Strohbach

Suvit Thaisrivongs

Steven Ronald Turner

David John Anderson

Gordon L Bundy

Ronald B Gammill

Paul A Aristoff

Mark E Schnute

John Alan Tucker

Harvey I Skulnick

Paul D Johnson

Steven Paul Tanis

Arthur Glenn Romero

Valerie Ann Vaillancourt

Ruben Alberto Tommasi

Scott D Larsen

Paul D May

Joel Morris

Louis L Skaletzky

Theresa M Schwartz

George P Luke

Richard Charles Thomas

Jeffrey H Tidwell

Clarence Webster Andrews, Iii

Paul K Tomich

George Andrew Freeman

Michele M Cudahy

James A Nieman

Joseph Howing Chan

Michael John Bohanon

Olivier Bezencon

Chih-Ping Yang

Lee S Banitt

Qingwei Zhang

Pascal Maurice Charles Pianetti

Euibong J Kim

The present invention includes benzophenone compounds (I) which are useful in the treatment of HIV infections.

Benzophenones as inhibitors of reverse transcriptase

The invention provides a compound of formula I:wherein G, R, and Rhave any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of treating a herpesvirus infection using such compounds or salts.

Antiviral agents

The invention provides a compound of formula I:wherein G, R, R, and Rhave any of the values defined in the specification, or a pharmaceutically acceptable salt thereof, as well as processes and intermediates useful for preparing such compounds or salts, and methods of preventing or treating a herpesvirus infection using such compounds or salts.

Antiviral compounds

The present invention provides for 8-hydroxy-7-substituted quinoline compounds such as formula IA

8-hydroxy-7-substituted quinolines as anti-viral agents

The present invention provides for 8-hydroxy-7-substituted quinoline compounds such as formula III

The present invention relates to compounds of formula I and II which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl&lsqb;b&rsqb;pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus.

Compounds useful to treat retroviral infections

The present invention provides 4-hydroxyquinoline-3-carboxamide and hydrazide compounds of formula I ##STR1## These compounds are useful to treat or prevent the herpesviral infections, particularly, human cytomegaloviral infection.

4-hydroxyquinoline-3-carboxamides and hydrazides as antiviral agents

Pyranone compounds useful to treat retroviral infections

4-hydroxy-benzopyran-2-ones and 4-hydroxy-cycloalkyl�b!pyran-2-ones

Growing community of inventors

Durham, NC, United States of America

Karen Rene Romines