Smithkline Beecham Corporation

Karen M O'Dwyer

Michael Terence Black

Richard Lloyd Warren

Caroline Perry

Min Wang

Nicola Gail Wallis

Magdalena Zalacain

Christopher Michael Traini

Deborah Dee Jaworski

David John Holmes

Sanjoy Biswas

Leslie Marie Palmer

Stephanie Van Horn

Lisa Kathleen Shilling

Karen Anne Ingraham

Howard Kallender

Jason Craig Fedon

Jeffrey L Mooney

John Timothy Lonsdale

John Peter Throup

Yi Yi Zhong

Chi Young So

Martin K R Burnham

Marie J Mazzulla

Glenn Scott Van Aller

Jeff Mooney

Serry Sousa

The invention provides Histidine Kinase polypeptides and polynucleotides encoding Histidine Kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Histidine Kinase polypeptides to screen for antibacterial compounds.

Histidine kinase

spsA polypeptides and DNA (RNA) encoding such spsA and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spsA for the treatment of infection, particularly bacterial infections. Antagonists against such spsA and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spsA nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding spsA and for detecting the polypeptide in a host.

spsA polynucleotides and polypeptides

The invention provides secA2 polypeptides and DNA (RNA) encoding secA2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing secA2 polypeptides to screen for antibacterial compounds.

Compounds

spsB polypeptides and DNA (RNA) encoding such spsB and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spsB for the treatment of infection, particularly bacterial infections. Antagonists against such spsB and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spsB nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding spsB and for detecting the polypeptide in a host.

Signal peptidase polypeptides of Staphylococcus aureus

spsA polynucleotides

The invention provides secA2 polypeptides and DNA (RNA) encoding secA2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are secA2 polynucleotides for use as diagnostic reagents.

Sec A2 from Streptococcus pneumoniae

The invention provides fabF polypeptides and polynucleotides encoding fabF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabF polypeptides to screen for antibacterial compounds.

FabF

Vectors carrying coding sequence for the SpsB protein of Staphylococcus

The invention provides secA1 polypeptides and DNA (RNA) encoding secA1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing secA1 polypeptides to screen for antibacterial compounds.

DNA encoding the SecA1 polypeptide of Staphylococcus aureus

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Phoenixville, PA, United States of America

Karen M O'Dwyer