The United States of America As Represented by the Administrator of the

Karen M Francis

Thomas John Goodwin

Glenn F Spaulding

Tacey L Prewett

Kim C O'Connor

Angela D Andrews

Laurie A Aten

Wendy S Fitzgerald

Delmar R Caldwell

A process for artificially producing three-dimensional optic tissue has been developed. The optic cells are cultured in a bioreactor at low shear conditions. The tissue forms as normal, functional tissue grows with tissue organization and extracellular matrix formation.

Three dimensional optic tissue culture and process

A process has been developed for recombinant production of selected polypeptides using transformed insect cells cultured in a horizontally rotating culture vessel modulated to create low shear conditions. A metabolically transformed insect cell line is produced using the culture procedure regardless of genetic transformation. The recombinant polypeptide can be produced by an alternative process using virully infected or stably transformed insect cells containing a gene encoding the described polypeptide. The insect cells can also be a host for viral production.

Recombinant protein production and insect cell culture and process

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Aiken, SC, United States of America

Karen M Francis