Bristol-Myers Squibb Compnay

Karen LeBoulluec

Graham Johnson

Graham S Poindexter

Marc A Bruce

Charles P Sloan

Michael R Kozlowski

Ivo Monkovic

Ramakrishna Seethala

Jeffrey W Noonan

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperidine and tetrahydropyridine derivatives of 4-phenyl-1,4-dihydropyridines of Formula I. ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

Dihydropyridine NPY antagonists: piperidine derivatives

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of piperazine and homopiperazine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

Dihydropyridine npy antagonists: piperazine derivatives

A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of nitrogen heterocyclic derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of NPY-induced feeding behavior, these compounds are expected to act as effective anorexiant agents in promoting weight loss and treating eating disorders.

Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives

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Wallingford, CT, United States of America

Karen LeBoulluec