Corning Glass Works

Ciba Corning Diagnostics Corp.

Karen L Travis

Albert A Luderer

Gerald R Mansfield

William P Vann

Brenda D Manning

Frank B Ward

Mary L Nicholson

Michael A Harvey

A substantially pure antigen found on normal and benign breast epithelial cell membranes and in breast cancer cells, fused cell hybrids which produce antibodies specific for such antigen, the monoclonal antibodies produced by such fused cell hybrids, a method for detecting the presence of breast cancer in a patient which is based on measuring the concentrations of one or more determinants of such antigen in a patient sample, and a method for either identifying those breast cancer patients whose tumors would respond to estrogen manipulation or determining prognosis based on the degree of differentiation, which method is based on measuring the concentration of an estrogen-modulated determinant of such antigen.

Monoclonal antibodies specific for 330 KD breast tumor antigen and assay

Solid-phase immunoassay procedures employing magnetic glass or crystal-containing material, or a superparamagnetic material formed of magnetic particles dispersed in a non-magnetic matrix, as particulate carrier.

Solid-phase immunoassays using magnetic glass

Thyroxine binding globulin (TBG) and thyroxine (T.sub.4) can be efficiently removed fron serum containing TBG and T.sub.4 by contacting the serum with finely-divided alumina particles to adsorb a major portion of the T.sub.4 and then reacting the serum at an acidic pH with an anion exchange resin to extract substantially all TBG and the remaining T.sub.4.

Preparation of serum standard for radioassay of thyroxine

Growing community of inventors

Corning, NY, United States of America

Karen L Travis