Curis, Inc.

Karen Kotkow

Lee L Rubin

Henryk T Dudek

Carmen Pepicelli

Irina Karavanov

The present application is directed to compositions and methods for inhibiting angiogenesis and treating or preventing unwanted cell proliferation, including tumors, by inhibiting the hedgehog pathway, e.g., with an antagonist of the hedgehog pathway such as those disclosed herein.

Methods of treating pancreatic or liver cancer using hedgehog antagonists

Methods of inhibiting unwanted cell proliferation using hedgehog antagonists

Hedgehog agonists and antagonists can be used to regulate angiogenesis, and to prevent angiogenesis driven pathologies. Furthermore, hedgehog agonists and antagonists have utility in modulating tissue repair and in the treatment of many forms of cancer.

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Jamaica Plain, MA, United States of America

Karen Kotkow