Trius Therapeutics, Inc.

Other

Janssen Pharmaceutica Nv

Basilea Pharmaceutica International Ag, Allschwil

Karen Joy Shaw

John M Finn

Robert Haselbeck

Vickie L Brown-Driver

Mark Hilgers

Mark Stidham

Kedar Gc

Cheryl A Grice

Hariharan Venkatesan

Laurent Gomez

Michael D Hack

John J M Wiener

Brett D Allison

Kimberly Schwarz

Alejandro Santillán, Jr

Liu Y Tang

Brian J Morrow

S Timothy Motley

Michael Trzoss

Jonathan A Covel

George H Miller

Kenneth Bartizal

Peter J Webb

Roberta S Hare

George H Shimer, Jr

Jeffrey Brian Locke

Philippe G Prokocimer

Described herein are heterocycle substituted pyridine derivative antifungal agents and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of fungal diseases and infections.

Heterocycle substituted pyridine derivative antifungal agents

A therapeutic combination comprises an antibacterially effective amount of daptomycin, and an amount of protein synthesis inhibitor antibiotic effective to prevent the development of daptomycin non-susceptibility in bacteria. Related combination therapies and methods are also included.

Therapeutic combination of daptomycin and protein synthesis inhibitor antibiotic, and methods of use

The present invention provides a pharmaceutical composition useful for treating bacterial infections in humans and animals which comprises administering to a human or animal in need thereof, an antibacterially effective combination of a &#x3b2;-lactam antibiotic and an inhibitor of any bacterial peptidoglycan biosynthesis enzyme, especially GlmU, GlmU, MurA, MurB, MurC, MurD, MurE, MurF, MurG, MraY, and UppS. Further provided is a method of discovering synergists for antibiotics including: a) expressing in a cell an antisense nucleic acid against a nucleic acid encoding a gene product so as to reduce the activity or amount of the gene product in the cell, thereby producing a cell sensitized to an antibiotic; b) characterizing the sensitization of the cell to the antibiotic and selecting pairs of antibiotics and genes that result in antibiotic efficacy at one-fifth or less the concentration required in the absence of the antisense gene; c) screening for chemical compounds that inhibit the gene product corresponding to the selected synergistic gene; and d) selecting or creating chemical analogs that inhibit the gene product corresponding to the selected synergistic gene such that the inhibition occurs in the bacteria.

Identification and application of antibiotic synergy

Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.

Bicyclic pyrazole compounds as antibacterial agents

The invention provides a method for generating and selecting drug-sensitizing antisense DNA fragments. In one embodiment, the method includes identifying a gene of interest using knowledge of bacterial physiology, biochemistry, genetics, genomics, and other means. The method includes PCR amplification of a gene of interest using genomic DNA as a template; fragmentation of the DNA by sonication or other means; selecting DNA fragments no longer than 400 base pairs; ligating the DNA fragments into a suitable expression plasmid with a selectable marker; transforming the plasmids containing the DNA fragments into the organism from which the gene of interest originated; and selecting clones from transformed cells that show a phenotypic difference of the clone grown in the presence of the inducer relative to the phenotype in the absence of inducer.

Method for identifying drug-sensitizing antisense DNA fragments and use thereof

The invention provides methods for identifying nucleic acids and polypeptides derived from fungi that are useful as antifungal targets for diagnosis and/or treatment of fungal diseases. The invention also provides isolated fungal-specific nucleic acids and polypeptides comprising antifungal targets. Methods for identifying antifungal agents that interact with and/or alter the function the antifungal targets are provided.

Method to identify fungal genes useful as antifungal targets

A device to assist in lifting and supporting a handicapped or infirm person from a sitting position on a supporting surface, and transferring the person to a sitting position on a second supporting surface. The device includes a main body portion of fabric or other flexible material having a configuration tending to conform naturally to the body contours of a person seated thereon. Flexible, strap-type handles are permanently installed on each side of the device and are selectively useable in either of two positions, providing relatively long and short, flexible handles; alternative, rigid handles are also provided. In a second embodiment, the body portion includes an elongated opening to permit the use of toilet facilities by a person seated on the device.

Patient support and lifting device

Growing community of inventors

Poway, CA, United States of America

Karen Joy Shaw