Millennium Pharmaceuticals Limited

Other

University of Utah Research Foundation

Karen J Moore

Patrick W Kleyn

Deborah Lynn Nagle

Charles M Perou

Jerry Kaplan

Carlos J Gimeno

Rosana Kapeller

Elizabeth A Woolf

The present invention relates to mammalian mahogany genes, including the human mahogany gene, which are novel genes involved in the control of mammalian body weight. The invention encompasses nucleotide sequences of the mahogany gene, host cell expression systems of the mahogany gene, and hosts which have been transformed by these expression systems, including transgenic animals. The invention also encompasses novel mahogany gene products, including mahogany proteins, polypeptides and peptides containing amino acid sequences mahogany proteins, fusion proteins of mahogany proteins polypeptides and peptides, and antibodies directed against such mahogany gene products. The present invention also relates to methods and compositions for the diagnosis and treatment of mammalian body weight disorders, including obesity, cachexia, and anorexia, and for the identification of subjects susceptible to such disorders. Further, the invention relates to methods of using the mahogany gene and gene products of the invention for the identification of compounds which modulate the expression of the mahogany gene and/or the activity of the mahogany gene product. Such compounds can be useful as therapeutic agents in the treatment of mammalian body weight disorders, including obesity, cachexia, and anorexia.

Compositions and methods for the diagnosis and treatment of body weight disorders, including obesity

Methods and composition for the diagnosis and treatment of body weight disorders, including obesity

The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian tub gene, a gene that is involved in the regulation of body weight.

Screening methods for compounds useful for the treatment of body weight disorders, including obesity

The present invention, which is based on the discovery of novel genes encoding rp polypeptides, features therapeutics, diagnostics and screening assays.

RP compositions and therapeutic and diagnostic uses therefor

The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the differentiation and/or function of intracellular vesicles. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian bg gene, a gene that, when mutated, is responsible or the human Chediak-Higashi syndrome.

Compositions for the diagnosis and treatment of Chediak-Higashi syndrome

Methods and compositions for the diagnosis and treatment of body weight disorders, including obesity

The invention provides isolated nucleic acids molecules, designated retinitis pigmentosa (&ldquo;rp&rdquo;) nucleic acid molecules, which encode polypeptides involved in the regulation of sensory functions, e.g., retinal functions, e.g., functions of the rod and cone photoreceptor cells of the retina, body weight, and/or metabolic functions. The invention also provides antisense nucleic acid molecules, expression vectors containing rp nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an rp gene has been introduced or disrupted. The invention still further provides isolated rp polypeptides, fusion proteins, antigenic peptides, and anti-rp antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.

RP compositions and diagnostic uses therefor

Compositions for the treatment and diagnosis of body weight disorders, including obesity

The present invention relates to antibodies which specifically bind to mammalian tub gene products, tub peptide fragments and tub peptides produced by genetically engineered cells.

Compositions for the treatment and diagnosis of body weight disorders,

The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the differentiation and/or function of intracellular vesicles. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian bg gene, a gene that, when mutated, is responsible for the human Chediak-Higashi syndrome.

The present invention relates to the discovery, identification and characterization of nucleic acids that encode a novel G protein coupled receptor (I5E) protein. The invention encompasses I5E nucleotides, host cell expression systems, I5E proteins, fusion proteins, polypeptides and peptides, antibodies to the receptor, transgenic animals that express an I5E transgene, or recombinant knock-out animals that do not express the I5E, antagonists and agonists of the receptor, and other compounds that modulate I5E gene expression or I5E activity that can be used for diagnosis, drug screening, clinical trial monitoring, and/or used to treat disorders such as inflammatory, central nervous system or gastrointestinal disorders.

Isolated DNA encoding a novel human G-protein coupled receptor

Methods for identifying compounds that bind to a mammalian tub protein

Methods for detecting mammalian tub protein and RNA

The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the control of mammalian body weight. The nucleic acid molecules of the present invention represent the gene corresponding to the mammalian tub gene, a gene that is involved in the regulation of body weight. The present invention also relates to methods for identifying compounds that modulate tub protein activity.

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Maynard, MA, United States of America

Karen J Moore