Signal Pharmaceuticals, Inc.

Karen J MacFarlane

Shripad S Bhagwat

Paul E Erdman

Yoshitaka Satoh

Adam Kois

Jason Parnes

Moorthy S S Palanki

Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure: wherein Rand Rare as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to IKK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto

Compounds having activity as inhibitors of IKK are disclosed, particularly IKK-2. The compounds of this invention are anilinopyrimidine derivatives having the following structure:wherein Rand Rare as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to IKK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

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San Diego, CA, United States of America

Karen J MacFarlane