Nps Pharmaceuticals, Inc.

Fmc Corporation

Karen J Krapcho

Robert M Kral, Jr

Janice H Johnson

Lance G Hammerland

John Randolph Jackson

Thomas M Stormann

Bradford C VanWagenen

J R Jackson

Eric G DelMar

Forrest H Fuller

Laura L Storjohann

Cynthia Levinthal

Eric G Delmar

A novel human metabotropic glutamate receptor (mGluR) protein is identified, sequenced, and cloned. The receptor may be used to screen for compounds that modulate the activity of the mGluR. The recombinant mGluR, as well as compounds that modulate mGluR activity, may be used in the diagnosis and treatment of neurological disorders and diseases.

Human metabotropic glutamate receptor

A novel human metabotropic glutamate receptor (mGluR) protein is identified, sequenced, and cloned. The receptor may be used to screen for compounds that modulate the activity of the mGluR. The recombinant mGluR as well as compounds that modulate mGluR activity may be used in the diagnosis and treatment of neurological disorders and diseases.

Nucleic acids encoding mGLuR/CaR chimera

This invention relates to the purification of a group of insecticidally effective toxins isolated from the wasp, Bracon hebetor, characterized by their neurotoxic effect on insect pest and low mammalian toxicity. The cDNA sequences for two of these toxins have been isolated, and the complete coding sequence is provided. This invention also discloses methods for producing recombinant toxins, as well as methods of utilizing these toxins as insecticidal agents.

16 KDA insecticidal toxin from bracons hebetor, nucleic acids encoding

The present invention provides chimeric receptors. The chimeric receptors comprise at least one region homologous to a region of a metabotropic glutamate receptor and at least one region homologous to a region of a calcium receptor. The invention also includes methods of preparing such chimeric receptors, and methods of using such receptors to identify and characterize compounds which modulate the activity of metabotropic glutamate receptors or calcium receptors. The invention also relates to compounds and methods for modulating metabotropic glutamate receptor activity and binding to metabotropic glutamate receptors. Modulation of metabotropic glutamate receptor activity can be used for different purposes such as treating neurological disorders and diseases, inducing an analgesic effect, cognition enhancement, and inducing a muscle-relaxant effect.

Chimeric receptors and methods for identifying compounds active at

Insecticidal toxins from Bracon hebetor nucleic acid encoding said toxin

This invention provides a family of insecticidally effective peptides which may be isolated from Tegenaria spider venom, DNA encoding such insecticidally effective peptides and methods for controlling invertebrate pests.

Insecticidally effective peptides

This invention provides a family of insecticidally effective proteins and particular members of that family which may be isolated from the venom of the spider Filistata hibernalis, DNA encoding such proteins, insecticidal compositions of these proteins or the DNA encoding them, and methods for controlling invertebrate pests. Recombinant expression vectors and host cells and methods for producing insecticidally effective peptides are also provided.

Recombinant expression of insecticidally effective spider toxin

This invention relates to the purification of a family of insecticidally effective peptides isolated from the spider, Calisoga sp., characterized by their neurotoxic effect on insect pest and low mammalian toxicity. The cDNA sequences for three of these peptides have been isolated, and the complete coding sequence is provided. This invention also discloses methods for producing recombinant peptides, as well as methods of utilizing these peptides as insecticidal agents.

Insecticidal peptides from spider venom

The invention provides insecticidally effective peptides isolatable from Diguetia spider venom, methods for preparing and using insecticides, and DNA encoding such insecticidally effective peptides.

Growing community of inventors

Salt Lake City, UT, United States of America

Karen J Krapcho