Phio Pharmaceuticals Corp.

Rxi Pharmaceuticals Corporation

Biogazelle Nv

Karen G Bulock

James Cardia

Anastasia Khvorova

Tod M Woolf

Joanne Kamens

William Salomon

Dmitry Samarsky

Pamela A Pavco

Lyn Libertine

Michael Francis Byrne

Michelle Miller

Gerard Cauwenbergh

Joke Hedwig Vandesompele

Gert Van Peer

Neutral lipid formulations for nucleic acid delivery are provided according to the invention. The neutral lipid formulations include hydrophobically modified polynucleotides and fat mixtures. Methods of using the neutral lipid formulations are also provided.

Neutral nanotransporters

Aspects of the invention relate to methods for treating cancer by administering to a subject in need thereof a therapeutically effective amount of a nucleic acid molecule that is directed against a gene encoding mouse double minute 1 homolog (MDM1), mouse double minute 2 homolog (MDM2), mouse double minute 3 homolog (MDM3), mouse double minute 4 homolog (MDM4) or V-myc myelocytomatosis viral related oncogene (MYCN) for treating cancer. Further aspects of the invention relate to nucleic acid molecules and compositions comprising nucleic acid molecules.

Methods for treating cancer using nucleic acids targeting MDM2 or MYCN

The present disclosure relates to RNAi constructs with improved cellular uptake characteristics and methods of use of these compounds for silencing expression of long coding RNAs (IncRNAs).

Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA

Aspects of the invention relate to methods for treating ALS comprising administering to a subject in need thereof a therapeutically effective amount of a nucleic acid molecule that is directed against a gene encoding superoxide dismutase 1 (SOD1).

Nucleic acid molecules targeting superoxide dismutase 1 (SOD1)

The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal and fibrotic applications.

RNA interference in dermal and fibrotic indications

Growing community of inventors

Mendon, MA, United States of America

Karen G Bulock