Warner-Lambert Company

Millennium Pharmaceuticals Limited

Karen Elaine Sexton

Helen Tsenwhei Lee

Stephen Alan Fakhoury

Bruce D Roth

Haile Tecle

Roy Thomas Winters

Kevin Matthew Schlosser

Jessica Elizabeth Reed

David T Connor

Bruce A Lefker

Stephen Douglas Barrett

Roderick J Sorenson

William Howard Roark

Lain-Yen Hu

Randy Ranjee Ramharack

Victor Fedij

Raj Kumar Raheja

Donna Michele Iula

Jennifer Ann Van Camp

Michael William Wilson

Jason Keith Pontrello

Robert Schaum

Stephanie Elizabeth Ault Justus

Bruce Allen Lefker

This invention provides quinazoline compounds of the formula: 

4-phenylamino-quinazolin-6-yl-amides

This invention provides quinazoline compounds of the formula: wherein: Ris halo; Ris H or halo; Ris a) C-Calkyl, optionally substituted by halo; or b) &#x2014;(CH)-morpholino, &#x2014;(CH)-piperidine, &#x2014;(CH)-piperazine, &#x2014;(CH)-piperazine-N(C-Calkyl), &#x2014;(CH)-pyrrolidine, or &#x2014;(CH)-imidazole; n is 1 to 4; Ris &#x2014;(CH)-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C-Calkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH, NH(C-Calkyl) or N(C-Calkyl); m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.

The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.

Androgen modulators

This invention provides quinazoline compounds of the formula: wherein: Ris halo; Ris H or halo; Ris a) C-Calkyl, optionally substituted by halo; or b) &#x2014;(CH)-morpholino, &#x2014;(CH)-piperidine, &#x2014;(CH)-piperazine, &#x2014;(CH)&#x2014;-piperazine-N(C-Calkyl), &#x2014;(CH)-pyrrolidine, or &#x2014;(CH)-imidazole; n is 1 to 4; Ris &#x2014;(CH)-Het; Het is morpholine, piperidine, piperazine, piperazine-N(C-Calkyl), imidazole, pyrrolidine, azepane, 3,4-dihydro-2H-pyridine, or 3,6-dihydro-2H-pyridine, each optionally substituted by alkyl, halo, OH, NH, NH(C-Calkyl) or N (C-Calkyl); m is 1-3; and X is O, S or NH; or a pharmaceutically acceptable salt thereof, as well as processes and intermediate compounds for making them, useful pharmaceutical compositions and methods of using the compounds in the treatment of proliferative diseases.

Antidiabetic agents

Thiourea and benzamide compounds, compositions and methods of treating or preventing inflammatory diseases and atherosclerosis

Thiazolidinone compounds useful as chemokine inhibitors

Sulfonamide compounds and methods of treating atherosclerosis and restenosis

The present invention provides compounds having the Formula I

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Chelsea, MI, United States of America

Karen Elaine Sexton