Bracco International Bv

Bracco Suisse Sa

Dyax Corporation

Bracco Imaging S.p.a.

E. R. Squibb Sons, Inc.

Bracco Diagnostics Inc.

Bracco Research, USA

Karen E Linder

Kondareddiar Ramalingam

Adrian D Nunn

Edmund R Marinelli

Palaniappa Nanjappan

Rolf E Swenson

Michael F Tweedle

Radhakrishna K Pillai

Natarajan Raju

Mathew A Von Wronski

Bo Song

Ajay Shrivastava

Hong Fan

Aaron Sato

Philippe Bussat

Daniel T Dransfield

Christophe Arbogast

Feng Yan

Luciano Lattuada

Sibylle Pochon

Enrico Cappelletti

Sharon Michele Walker

David P Nowotnik

Richard J DiRocco

William L Rumsey

John P Pirro

Ramachandran S Ranganathan

Thangavel Arunachalam

Paul W Wedeking

Sudha Khurana

Robert Charles Ladner

Michel Schneider

John J Niedospial, Jr

Daniel J Sexton

Ruth Wager

Jason M Voytilla

Silvia Jurisson

Ruth E Wager

Hong (Helen) Fan

Lynn C Francesconi

Aldo Cagnolini

William C Eckelman

Mary Ellen Maddalena

Sybille Pochon

Nataranjan Raju

Jianqing Chen

Nannan Wang

Richard J Di Rocco

Aaron K Sato

The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K&#x3c;1 &#x3bc;M), and dimer and multimeric constructs comprising these polypeptides.

KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy

The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K&#x3c;1 &#x3bc;M), and dimer and multimeric constructs comprising these polypeptides, particularly contrast agents. Also provided are methods for monitoring and evaluating the therapeutic effectiveness of treatment protocols for diseases associated with angiogenesis or endothelial cell hyperproliferation, such as cancer, using contrast agents of the invention.

The invention provides compositions and methods for therapeutic and diagnostic applications.

Multivalent constructs for therapeutic and diagnostic applications

New and improved compounds for use in diagnostic imaging or therapy having the formula M-N&#x2014;O&#x2014;P-G, wherein M is a metal chelator having the structure: wherein R1-R5 and FG are as defined herein (in the form complexed with a metal radionuclide or not), N&#x2014;O&#x2014;P is the linker containing at least one non-alpha amino acid with a cyclic group, at least one substituted bile acid or at least one non-alpha amino acid, and G is the GRP receptor targeting peptide. In the preferred embodiment, M is an Aazta metal chelator or a derivative thereof. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound is further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.

Gastrin releasing peptide compounds

Novel methods of treating prostate tumors or of delaying the progression of prostate tumors are also provided, including, methods of treating bone or soft tissue metastases of prostate cancer methods for treating hormone sensitive and hormone refractory prostate cancer, methods for delaying the progression of hormone sensitive prostate cancer, for facilitating combination therapy in patients with hormone sensitive prostate cancer and for decreasing aberrant vascular permeability in patients with hormone sensitive prostate cancer, said methods comprising the step of administering to a subject a dose comprising an amount of radioactively labeled L70, N-[4-[[[[[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]amino]acetyl]amino]benzoyl]-L-glutaminyl-L-tryptophyl-L-alanyl-L-valyl-glycyl-L-histidyl-L-leucyl-L-methioninamide. 

Improved compounds for use in diagnostic imaging or therapy having the formula M-N-O-P-G, wherein M is an optical label or a metal chelator (in the form complexed with a metal radionuclide or not), N-O-P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy or phototherapy to a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound are further provided. Methods and kits for preparing a radiotherapeutic agent are further provided.

New and improved compounds for use in radiodiagnostic imaging or radiotherapy having the formula M-N&#x2014;O&#x2014;P-G, wherein M is the metal chelator (in the form complexed with a metal radionuclide or not), N&#x2014;O&#x2014;P is the linker, and G is the GRP receptor targeting peptide. Methods for imaging a patient and/or providing radiotherapy to a patient using the compounds of the invention are also provided. A method for preparing a diagnostic imaging agent from the compound is further provided. A method for preparing a radiotherapeutic agent is further provided.

A vial enshrouded or contained in a protective covering which prevents emission of radiation form the vial contents, shielding the environment and personnel from irradiation. The vial optionally has a V-shaped bottom to allow withdrawal of a maximal amount of the fluid without inverting the vial. The vial is equipped with a vial access adapter having a fluid withdrawal spike which extends in to the V-shaped bottom. The vial access adapter may be vented or non-vented.

Tabletop drug dispensing vial access adapter

The present invention provides compounds for targeting endothelial cells, tumor cells or other cells that express the NP-1 receptor, compositions containing the same and methods for their use. Additionally, the present invention includes diagnostic, therapeutic and radiotherapeutic compositions useful for visualization, therapy or radiotherapy.

Compounds for targeting endothelial cells, compositions containing the same and methods for their use

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Kingston, NJ, United States of America

Karen E Linder