Albumedix Limited

Albumedix A/s

Sartorius Albumedix Limited

Novozymes Biopharma Dic A/s

Karen Ann Delahay

Jan Terje Andersen

Jason Cameron

Andrew Plumridge

Jens Erik Nielsen

Christopher John Arthur Finnis

Karl Michael Nicholls

Esben Peter Friis

Inger Sandlie

Bjorn Dalhus

Christopher John Finnis

The present invention relates to conjugation-competent albumins and albumin-related polypeptides, and their conjugates with at least one moiety, and to polynucleotides encoding them.

Albumin variants and conjugates

The present invention relates to variants of a parent albumin, the variants having altered plasma half-life compared with the parent albumin. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants.

Albumin variants

Variants of a parent albumin having altered plasma half-life compared with a parent albumin are described. Fusion polypeptides and conjugates including the variant albumin are also described. Embodiments include, but are not limited to, a polypeptide which is a variant of albumin, including one or more alterations at one or more positions corresponding to 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119 and 120 in SEQ ID NO: 2.

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Nottingham, United Kingdom

Karen Ann Delahay