Ceskoslovenska Akademie Ved

Baylor College of Medicine

Karel Smetana

Jiri Sulc

Zuzana Krcova

Sarka Pitrova

Harris Busch

Rose K Busch

Phyllis Gyorkey

Frances M Davis

Ferenc Gyorkey

The invention pertains to a soft intracameral lens determined for the location in the posterior chamber of eye. The soft intracameral hydrogel lens has its front supporting and centering convex part determined for leaning against iris having in front a rotation symmetrical shape of a sphere, paraboloid or hyperboloid and passing into the broadest circumference by a surface which shape is equal to or approaches a shape of lateral area of cone, while the hinder supporting part of the lens with a spherical, planar, or moderately convex or concave-curved shape for leaning against a hinder capsula or a membrane from vitreous body in a large surface area. The hinder supporting part is broadened and forms on the edge a retaining ring reaching over the front part as much as by 1.5 mm, whereas the central thickness of the lens ranges between 1 to 3.5 mm. The surface of the soft intracameral lens may be formed, at least in part, from a soft hydrogel containing at least 70% of water at 20.degree. C. in the state of equilibrium swelling. the lens may have a spherical shape and be provided on the circumference with a supporting collar from soft hydrogel. The lens may also contain inside in its optical axis an inner part, e.g. a Fresnel lens, with a higher refractive index of light than has the surrounding part of the lens.

Soft intracameral lens

The invention pertains to a soft intracameral lens intended for location in the posterior chamber of the eye. The soft intracameral hydrogel lens has a front supporting and centering convex part intended for leaning against the iris having a rotational symmetrical shape of a sphere, paraboloid, or hyperboloid and passing into the broadest circumference by a surface, the shape of this surface being equal to or approaching the shape of the lateral area of a cone, while the hinder, or rear, supporting part of the lens has a spherical, planar, or moderately convex or concave-curved shape and a large surface area for leaning against a hinder capsula or a membrane of the vitreous body. The hinder supporting part is broadened and forms on its edge a retaining ring which reaches over the front part by as much as 1.5 mm, whereas the central thickness of the lens ranges between 1 to 3.5 mm. The surface of the soft intracameral lens may be formed, at least in part, from a soft hydrogel containing at least 70% water at 20.degree.C. in the state of equilibrium swelling. The lens may have a spherical shape and be provided on the circumference with a supporting collar manufactured from a soft hydrogel. The lens may also contain inside, in its optical axis, an inner part, e.g., a Fresnel lens, having a higher refractive index of light than the material which surrounds the inner part of the lens.

Specific common nucleolar antigens are found in a broad range of human malignant tumor specimens and have been isolated, extracted and purified. Antibodies and antisera specific to these nucleolar antigens are harvested from non-human hosts and used for detection of human cancer cells. Disclosed are (1) methods for isolating the nucleolar antigens, obtaining them in substantially purified form, producing the specific antibodies, obtaining them in substantially purified form, and using the antisera and antibodies induced by the nucleolar antigens in diagnostic procedures for detecting human cancer cells, and (2) diagnostic kits comprising specific antibodies and antisera.

Detection of human cancer cells with antibodies to human cancer

Growing community of inventors

Prague, Czechia

Karel Smetana