Univerzita Palackeho V Olomouci

Ustav Experimentalni Botaniky Av Cr, V.v.i.

Ustav Experimentalni Botaniky Akademie Ved Ceske Republiky

Freie Universitat Berlin

Bioapex, S.r.o.

Institute of Experimental Botany, Academy of Sciences of the Czeck Republic

Biopatterns, S.r.o.

Institute of Experimental Botany, Academy of Sciences of the Czech Republic

Univerzita Palackego V Olomouci

Syngenta Participations Ag

Karel Dolezal

Miroslav Strnad

Marek Zatloukal

Lukas Spichal

Jiri Voller

Lucie Plihalova

Igor Popa

René Lenobel

Jiri Gruz

Ondrej Plihal

Frank J Massino

Lucie Szucova

Stefaan Werbrouck

Vladimir Krystof

Libor Havlicek

Borivoj Vojtesek

Alena Kadlecova

Jan Holub

Petr Galuszka

Vaclav Mik

Jitka Vostalova

Alena Rajnochova Svobodova

Jitka Ulrichova

Jaroslav Nisler

Hana Vylicilova

Radoslav Koprna

Tomas Werner

Radek Jorda

Marketa Gemrotova

Jitka Frebortova

Dana Hradecká

Stjepan Uldrijan

Petr Mlejnek

Jana Bibova

Jan Walla

Tomas Gucky

Lenka Zahajska

Magdalena Bryksova

Adeyemi Oladapo Aremu

Aloka Kumari

Ponnusamy Baskaran

Johannes Van Staden

Tomas Pospisil

Jana Klaskova

Martin Hönig

Dana Hradeck

Frantisek Skarupa

Ludek Frohlich

Thomas Schmulling

Jarmila Balonova

Dardan Klos

A para-topolin mesylate salt and its crystalline form is disclosed. Cosmetic and therapeutic applications, and compositions containing this compound, are also disclosed. Mesylate salt of para-topolin has a wide range of biological activities, including antioxidative, anti-inflammatory, anti-senescent and anti-aging while showing low toxicity and excellent solubility.

Mesylate salt of para-topolin, compositions containing said salt and use thereof

The invention relates to N,N-disubstituted-9-(2-oxacycloalkyl)-9H-purine-2, 6-diamine derivatives and their use as drugs and cosmetics. The compounds of the present invention exhibit a number of biological activities associated with oxidative stress inhibition, especially anti-aging, anti-inflammatory and anti-neurodegenerative biological activities. The invention also relates to cosmetic and pharmaceutical compositions containing such derivatives as active agents.

9-(2-oxacycloalkyl)-9H-purine-2,6-diamine derivatives and their use for the treatment of skin disorders

Adenine derivatives substituted at the C2, N6, and N9 purine positions having antisenescent and combined photoprotective UVA/UVB effects. These substances are particularly suitable as anti-senescent and UV-photoprotective component in cosmetic preparations, plant protection preparations and in preparations for the treatment/application of tissue cultures. 

Adenine derivatives and their use as UV-photoprotective agents

The invention relates to substituted 6-anilino-9-heterocyclylpurine derivatives of formula I wherein R denotes one to five substituents independently selected from the group hydrogen, halogen, hydroxy, amino, alkyloxy and alkyl group, R2 is selected from the group comprising amino, halogen, hydroxy, thio, and alkylthio group, Cyc is five- or six-membered heterocyclic ring containing one oxygen atom. The derivatives are useful for inhibition of plant stress.

Substituted 6-anilino-9-heterocyclylpurine derivatives for inhibition of plant stress

6-aryl-9-glycosidpurines of general formula I and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts with acids, wherein

6-aryl-9-glycosylpurines and use thereof

6-aryl-9-glycosidpurines of general formula I and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts with acids, whereinGly represents &#x3b2;-D-arabinofuranosyl or &#x3b2;-D-2'-deoxyribofuranosyl,Ar represents benzyl or furfuryl, each of which can be unsubstituted or substituted by one or more, preferably one to three, substituents selected from the group comprising hydroxyl, alkyl, halogen, alkoxy, amino, mercapto, carboxyl, cyano, amido, sulfo, sulfamido, acyl, acylamino, acyloxy, alkylamino, dialkylamino, alkylmercapto, trifluoromethyl, trifluoromethoxy, for use as antisenescent and UV protective compounds in animals.

6,8-Disubstituted-9-(heterocyclyl)purines for use in pharmaceutical and cosmetic compositions and applications are provided. These 6,8-disubstituted-9-(heterocyclyl)purines have a wide range of biological activities, including for example antioxidant, anti-inflammatory, anti-senescent, anti-aging, as well as well as other activities which are especially useful in pharmaceutical and cosmetic applications. Compositions may include additional excipients and auxiliary substances. Methods of treatment of animals, mammals, plants, cells, yeast, and cells in tissue culture are also disclosed.

6,8-disubstituted-9-(heterocyclyl)purines, compositions containing these derivatives and their use in cosmetic and medicinal applications

Substituted 1,2,3-thiadiazol-5yl-urea derivatives, their use as anti-senescence and anti-stress factors of plant cells, organs and the whole plant, and preparations containing these derivatives.

1,2,3-thiadiazol-5yl-urea derivatives, use thereof for regulating plant senescence and preparations containing these derivatives

The invention relates to 6-substituted 9-halogenalkyl purine derivatives of the general formula I wherein R6 is selected from the group comprising &#x2014;NH-furfuryl, &#x2014;NH-(4-hydroxy-3-methylbut-2-en-1-yl), &#x2014;NH-(3-methylbut-2-en-1-yl), &#x2014;NH-(4-hydroxy-3-methylbutyl), &#x2014;NH-(4-hydroxy-1,3-dimethylbut-2-en-1-yl), &#x2014;NH-(4-hydroxy-1,3-dimethylbutyl), &#x2014;NH-benzyl, &#x2014;NH-phenyl, wherein benzyl, furfuryl and phenyl can be unsubstituted or optionally substituted with 1 to 3 substituents selected from the group comprising hydroxy, halogen, methyl and methoxy, and R9 is selected from the group comprising C-Calkyl or C-Calkenyl wherein each of the groups is substituted with one or more halogen atoms, for use in the regulation of growth and development of plant cells, organs and/or whole plants. The invention also relates to preparations containing these derivatives and to novel to 6-substituted 9-halogenalkyl purines.

Use of 6-substituted 9-halogenalkyl purines for regulation of growth and development of whole plants, plant cells and plant organs; novel 6-substituted 9-halogenalkyl purines

The invention relates to substitution derivatives of N-benzyladenosine-5'-monophosphate of the general formula I, wherein (R)represents 1 to 4 substituents (n is in the range 1-4), which can be the same or different, and R is selected from the group comprising Cto Calkyl, Cto Calkoxy, amino, halogen, hydroxy, mercapto and nitro groups, and the pharmaceutically acceptable salts thereof. This invention also relates to methods of their preparation, their use as medicaments and in other biotechnological applications, and a therapeutic composition containing these derivatives.

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The invention relates to new substituted 6-(2-aminobenzylamino)purines, represented by the general formula I, which can be used in CDK inhibition, in particular, in the treatment of viral infections and diseases involving cell proliferation. The invention further includes pharmaceutical preparations containing substituted 6-(2-aminobenzylamino)purines.

Substituted 6-(2-aminobenzylamino)purine derivatives, their use as medicaments and preparations containing these compounds

Certain 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts of the general formula are provided wherein Rand Rare as defined in the specification. These 6,9-disubstituted purine derivatives and their pharmaceutically acceptable salts are useful in compositions for treating mammalian cells, and especially human skin cells, in order to ameliorate the adverse effects of aging, treat skin disease states, treat immunological responses resulting from or associated with inflammation, and the like.

6, 9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions

Novel heterocyclic derivatives based on N-substituted adenine, having anticancer, mitotic, immunosuppressive and antisenescent properties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.

The invention relates to substituted 6-(2-hydroxybenzylamino)purines of general formula I, to their activity as cyclin-dependent kinases 2, 5, 7 and 9 inhibitors and to their use as medicaments, particularly in the treatment of disorders involving cell proliferation or inflammation. The invention further includes pharmaceutical compositions containing the substituted 6-(2-hydroxybenzylamino)purines. 

Substituted 6-(2-hydroxybenzylamino)purine derivatives, their use as medicaments and compositions containing these derivatives

The invention relates to substituted 6-anilinopurine derivatives of the general formula I, wherein R denotes one to five substituents independently selected from the group consisting of hydrogen, halogen, hydroxyl, amino, alkyloxy and alkyl group, and R2 denotes amino, halogen, nitro, thio, alkylthio or alkyl group for use as inhibitors of cytokinin oxidase/dehydrogenase. The invention also relates to the compositions containing these derivatives.

Substituted 6-anilinopurine derivatives as inhibitors of cytokinin oxidase/dehydrogenase and preparations containing these derivatives

Growing community of inventors

Hlubocky, Czechia

Karel Dolezal