USA As Represented by Secretary of the Navy

US Government As Represented by the Secretary of the Army

Kara E Schmid

Frank Casper Tortella

Mark W Brown

Thomas J Palys

Xi-Chun May Lu

Larry R Holmes, Jr

Jitendra Ramanlal Dave

Zachary J Larimore

Deborah A Shear

Randal J Schoepp

Mark F Arnold

Lai Yee Leung

Zhilin Liao

Jay E Bartlett

Mark P Easterday

Andrea Mountney

Zhiyong Chen

An apparatus and method for inflicting brain injury on a laboratory animal that employs a platform for supporting the laboratory animal. The platform defines an opening for positioning the head of the laboratory animal over the opening. A projectile is launched from a projectile launching device orientated below the opening of the platform. The projectile launching device has a means for propelling the projectile directly at and/or through the opening of said platform, thereby inflicting brain injury on the animal via either a pressure wave or concussive impact of the projectile. Without helmet, direct impact of the projectile results in severe traumatic brain injury. Use of helmet protects animals from skull fracture, subdural hematoma, intracerebral hemorrhage and contusion yet produces mild concussion-like pathology.

Device and method for inducing brain injury in animal test subjects

In this application is described the production of recombinant, chimeric, humanized antibodies specific for both BoNt/A and BoNT/B. The humanized antibodies were converted from a mouse anti-BoNT/A/B Fab fragment into a whole human IgG1 antibody. The antibodies are useful in assays for detecting human exposure to BoNT/A and BoNT/B.

Recombinant chimeric human anti-botulinum antibodies

Growing community of inventors

Germantown, MD, United States of America

Kara E Schmid