Cancer Research Technology Limited

Kudos Pharmaceuticals Limited

Kappusamy Saravanan

Keith Allan Menear

Niall Morrison Barr Martin

Bernard Thomas Golding

Graeme Cameron Murray Smith

Roger John Griffin

David Richard Newell

Ian Robert Hardcastle

Nicola Curtin

Marc Geoffrey Hummersone

Hilary Alan Calvert

Laurent Jean Martin Rigoreau

Xiao-ling Fan Cockcroft

Mark Frigerio

Marine Desage-El Murr

A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: Rand Rare independently selected from hydrogen, an optionally substituted Calkyl group, Cheterocyclyl group, or Caryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is &#x2014;NH&#x2014;C(&#x2550;O)&#x2014; or &#x2014;O&#x2014;; Y is an optionally substituted Calkylene group; X is selected from SRor NRR, wherein, R, or Rand Rare independently selected from hydrogen, optionally substituted Calkyl, Caryl, or Cheterocyclyl groups, or Rand Rmay together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is &#x2014;O&#x2014;, X is additionally selected from &#x2014;C(&#x2550;O)&#x2014;NRR, wherein Rand Rare independently selected from hydrogen, optionally substituted Calkyl, Caryl, or Cheterocyclyl groups, or Rand Rmay together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is &#x2014;NH&#x2014;C(&#x2550;O)&#x2014;, &#x2014;Y&#x2014;X may additionally be selected from Calkyl.

DNA-PK inhibitors

Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of:

A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein:

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Newcastle upon Tyne, United Kingdom

Kappusamy Saravanan