Pfizer Corporation

Other

Kaoru Shimada

Fumitaka Ito

Masami Nakane

Hiroshi Kondo

John Adams Lowe, Iii

Terry J Rosen

Kunio Satake

Kazuo Ando

Yuji Shishido

Takashi Mano

Nobuko Asai

Fumiharu Naganeo

Mayumi Mizutani

Quinuclidine derivatives

This invention relates to a method for evaluating the susceptibility of pharmaceutical drugs to metabolism by a specific cytochrome P-450 isozyme, which comprises contacting the sample compound with a reagent composition prepared by adding the specific cytochrome P-450 isozyme to liver microsomes lacking said specific cytochrome P-450 isozyme in a carrier material. More particularly, this invention relates to a useful in vitro quantitative assay for drug metabolism by P-450 isozymes such as CYP2D6, CYP2C19, and CYP2A6. This invention also relates to a reagent composition which is useful for said in vitro assay.

Method for evaluating drug metabolism and reagent compositions therefor

Compounds of the formula ##STR1## wherein R.sup.1 is methoxy and R.sup.2 is selected from the group consisting of methyl, ethyl, isopropyl, sec-butyl and tert-butyl; and the pharmaceutically acceptable salts of such compounds. These compounds are substance P antagonists and useful in the treatment of gastrointestinal disorders, inflammatory disorders, central nervous system disorders and pain.

Quinuclidine derivative as a substance P antagonist

Substituted benzylaminoquinuclidines as substance P antagonists

Pyrimido-benzothiazines

This invention relates to certain benzoxazolinones which inhibit lipoxygenase and/or cyclooxygenase enzymes. Such compounds are useful in inhibiting such enzymes, per se, and are useful in treating allergic and inflammatory conditions in a mammal. This invention also relates to methods of inhibiting lipoxygenase and/or cyclooxygenase in a mammal with such benzoxazolinones; methods of treating an allergic condition in a mammal with such compounds; methods of treating an inflammatory condition in a mammal with such compounds; and pharmaceutical compositions comprising the benzoxazolinones hereof.

Antiallergy and antiinflammatory benzoxazolinones

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Okazaki, Japan

Kaoru Shimada