Bridgestone Sports Co., Ltd.

Keio University

Chugai Seiyaku Kabushiki Kaisha

Sony Corporation

Kaoru Ogawa

Hideyuki Okano

Masato Fujioka

Tatsuo Matsunaga

Makoto Hosoya

Sho Kanzaki

Hirotaka James Okano

An object of the present invention is to provide novel apoptosis inhibitors and therapeutic agents for inner ear hearing impairment. As a pharmaceutical agent for this purpose, biguanide compounds represented by the following structural formula (I) or a rapamycin derivative represented by the following structural formula (II) as an active ingredient is provided: wherein Rto Rare each independently selected from a hydrogen atom, a halogen atom, or a Calkyl group, a Ccycloalkyl group, a Caryl group, a 5- or 6-membered heteroaryl group, or a 5- or 6-membered non-aromatic heterocyclic group, each of which may have a substituent selected from a halogen atom, a cyano group, a Calkyl group, a Calkoxy group, a Calkoxy carbonyl group, a Ccycloalkyl group, a Calkenyl group, a Calkynyl group, and a phenyl group; wherein Ris a Calkyl or a Calkynyl, Ris H, &#x2014;CH2-OH or &#x2014;CH&#x2014;CHOH, and X is &#x2550;O, (H, H) or (H, OH).

Therapeutic agents for inner ear hearing impairment

An object of the present invention is to provide novel apoptosis inhibitors and therapeutic agents for inner ear hearing impairment. As a pharmaceutical agent for this purpose, biguanide compounds represented by the following structural formula (I) or a rapamycin derivative represented by the following structural formula (II) as an active ingredient is provided: wherein Rto Rare each independently selected from a hydrogen atom, a halogen atom, or a Calkyl group, a Ccycloalkyl group, a Caryl group, a 5- or 6-membered heteroaryl group, or a 5- or 6-membered non-aromatic heterocyclic group, each of which may have a substituent selected from a halogen atom, a cyano group, a Calkyl group, a Calkoxy group, a Calkoxy carbonyl group, a Ccycloalkyl group, a Calkenyl group, a Calkynyl group, and a phenyl group; wherein Ris a Calkyl or a Calkynyl, Ris H, &#x2014;CH2-OH or &#x2014;CH&#x2014;CH&#x2014;OH, and X is &#x2550;O, (H, H) or (H, OH).

A therapeutic and/or preventive agent for inner ear disorders comprising an IL-6 antagonist, preferably an anti-IL-6R antibody, as an active ingredient.

Therapeutic agents for inner ear disorders containing an IL-6 antagonist as an active ingredient

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Tokyo, Japan

Kaoru Ogawa