Eisai Company, Limited

Other

Eisai R&d Management Co., Ltd.

Kaoru Murata

Naoki Asakawa

Nariyasu Mano

Yasushi Ishihama

Shigeto Negi

Yosuke Iwata

Keisuke Matsuyama

Kenji Hayashi

Masanobu Shinoda

Fumiyoshi Matsuura

Manabu Sasho

Katsutoshi Nishiura

Mamoru Miyazawa

Naoki Ozeki

Susumu Inoue

Masaharu Gotoda

Katsuaki Kaito

Teiji Takigawa

Eiichi Yamamoto

Yoshihiko Hisatake

The present invention relates to calcium bis[(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy) -2-fluoropropoxy]phenyl]-2-isopropoxypropionate] represented by formula (I), a hydrate thereof, a crystal of the compound of formula (I), and a crystal of the hydrate of the compound of formula (I) which are useful as pharmaceuticals, and to processes for producing the same, and intermediates therefore, and processes for production thereof. There is need for (2S)-3-[3-[(2S)-3-(4 -chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, in the form of a drug substance, purified so as to minimize a residual solvent content and having a uniformized specification and a highly favorable workability, and a process for producing the same. Crystalline calcium bis[(2S)-3-[3-[(2S)-3-(4 -chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionate], a calcium salt of (2S) -3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl]-2-isopropoxypropionic acid, solves the above problem.

Calcium bis [(2S)-3-[3-[(2S)-3-(4-chloro-2-cyanophenoxy)-2-fluoropropoxy]phenyl ]-2-isopropoxypropionate] and intermediate thereof

Device for improving detection sensitivity in low flow velocity high performance liquid chromatographic apparatus. Preferredly, diffusion promoting device connected at just before separation column and having function of improving detection sensitivity for use in low flow velocity high performance liquid chromatographic apparatus. Also, method for improving detection sensitivity in low flow velocity high performance liquid chromatographic apparatus.

Diffusion promoting device for low flow velocity gradient high performance liquid chromatography

The present invention provides a packing for chromatography. Specifically, it provides a packing for chromatography in which a hydrophilic polymeric material is bound to the surface of a porous carrier, and a carbon chain is chemically bound inside the pore. By the use of the packing according to the present invention for analysis of low molecular weight compounds in a biological sample, a pretreatment such as removal of proteins etc. becomes unnecessary, and the biological sample can be directly analyzed.

Column packaging for chromatography

The present invention provides a device for improving detection sensitivity and a method for improving the detection sensitivity for use in a low flow velocity high performance liquid chromatographic apparatus. That is, the present invention is a diffusion promoting device connected at just before a separation column and having a function for improving detection sensitivity for use in a low flow velocity high performance liquid chromatographic apparatus.

Diffusion promoting apparatus for low flow velocity gradient high-speed liquid chromatography

The present invention provides a device capable of simply formulating an arbitrary gradient pattern in a low flow gradient high performance liquid chromatography. That is, the present invention provides a split tubing apparatus for a gradient high performance liquid chromatography, which comprises a solvent inlet part, a split tubing part split into two or more plural tubes, and a solvent outlet part.

Splitted tubing apparatus for gradient high performance liquid chromatography

A sample solution is sent into a concentration column through a three-way joint and a three-way switching valve to trap and concentrate the sample components on the concentration column, followed by injecting the sample solution into an injector by operating a first dilution solvent pump. When a large volume of the sample solution is to be sent or when the sample solution has a high solvent strength, trapping and concentration on the concentration column may be facilitated by replacing the sample solvent with a second dilution solvent by allowing the second dilution solvent to flow into the three-way joint after setting the flow rate of the second dilution solvent from a second dilution solvent vessel to a prescribed flow rate using a second dilution solvent pump.

Liquid chromatograph

Growing community of inventors

Ibaraki, Japan

Kaoru Murata