Oriental Yeast Co., Ltd.

Nippon Mining Co., Ltd.

Kyoto University

Kaoru Miyazaki

Yasuo Suzuki

Kazutoshi Takahashi

Hisataka Yasuda

Takekazu Horio

Katsumi Fujii

Hiraku Saito

Shouichi Higashi

Junko Hashimoto

Yoshinobu Kariya

Karuo Takaku

Miho Aoshima

Munehiro Yamada

Disclosed is an agent for improving at least one activity selected from the group consisting of the growth activity, adhesion activity and extension activity of mesenchymal stem cells, which comprises laminin-5 as an active ingredient. A method of culturing mesenchymal stem cells; a method of isolating mesenchymal stem cells; and a medium, vessel or sheet for use in culturing mesenchymal stem cells are also provided.

Technique for culture of mesenchymal stem cell utilizing laminin-5

The present invention provides a novel modified TIMP wherein the NH -terminal &agr;-amino group thereof is modified with an electron-accepting group to substantially lose the ability to bind to a metalloproteinase.

Modified timp

The present invention relates to a .beta.AP decomposing agent or a medicine for preventing and curing Alzheimer's disease, which contains, as the active ingredient, gelatinase A, a limited decomposate of gelatinase A, progelatinase A, a complex to which any of them has bonded or a material containing any of them. .beta.AP is a substance which is considered to cause Alzheimer's disease.

Method for decomposing amyloid protein precursor and amyloid

The present invention relates to a gelatinase A inhibitor comprising as an active ingredient a peptide analogue consisting of an active minimum unit of gelatinase A inhibition obtained from APP (.beta.-amyloid precursor) or a peptide analogue comprising it. Gelatinase A can be qualified and quantified using any of the gelatinase A inhibitors according to the present invention.

Gelatinase A inhibitor, and analytical reagent thereof for the

A novel arginine deiminase of an approximately 45,000 molecular weight derived from mycoplasma having an ability to decompose arginine, and the method of manufacturing this novel enzyme from mycoplasma. This enzyme is an effective anti-cancer agent, as it shows anti-cancer activities both in vitro and in vivo.

Arginine deiminase from a Mycoplasma arginini strain

Colored proteins having a known molecular weight of 1800 to 321200 are prepared by coupling monomers of a colored protein having a known molecular weight or by coupling a colored protein having a known molecular weight with a colorless protein having a known molecular weight. At least two proteins are selected from the so prepared colored proteins and used as a colored molecular weight marker. This colored molecular weight marker is used for determination of the molecular weight of a protein having an unknown molecular weight, and can also be used as a reference protein for purification of a protein having a known molecular weight.

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Kanagawa, Japan

Kaoru Miyazaki