Takeda Chemical Industries, Inc.

Kaoru Makino

Masaki Sokukawa

Yoshihiro Yasumura

There is disclosed a process for producing lower alkyl 2-keto-L-gulonate which comprises reacting 2-keto-L-gulonic acid with a lower alcohol in the presence of an acid, and simultaneously distilling off the resulting water together with the lower alcohol while continuously introducing a lower alcohol. By using the lower alkyl 2-keto-L-gulonate thus produced, L-ascorbate can be prepared in high purity and high yield.

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Toyonaka, Japan

Kaoru Makino