Other

Takara Shuzo Co., Inc.

Takara Bio Inc.

Research Institute for Glycotechnology

Kaoru Kojima

Ikunoshin Kato

Katsushige Ikai

Takeshi Sakai

Kazuo Shimanaka

Hitomi Kimura

Yoshikuni Nakanishi

Sumiko Akiyoshi

Kaoru Katayama

Takanari Tominaga

Takashi Kawai

Fu-Gong Yu

Hideo Kitano

Hitomi Amarume

Shinji Nakayama

Nobuto Koyama

Tatsuji Enoki

Kumiko Ishizuka

Three enzymes degrading sulfated glucuronofucan; processes for producing these enzymes; activators for these enzymes; glucuronofucan sulfate and degradation products thereof; and a novel microorganism.

Glucuronofucan sulfate

A smaller molecule obtainable by allowing a sulfated fucan-digesting enzyme which digests a novel sulfated polysaccharide derived from an alga belonging to Laminariales to act on a sulfated fucan, and a method for producing the same.

Sulfated fucan oligosaccharide

Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.

Apoptosis inducers

Sulfated fucogalactan or its salt useful as a reagent for sugar chain engineering or an HGF-production inducer; a degraded product or its salt obtained by treating the sulfated fucogalactan with a sulfated fucogalactan digesting enzyme; the sulfated fucogalactan digesting enzyme useful in sugar chain engineering; a process for producing the degraded product by treating sulfated fucogalactan or its salt with the above enzyme; and a process for producing the sulfated fucogalactan digesting enzyme.

Sulfated fucogalactan

Biologically pure culture of Fucoidanobacter marinus SI-0098 (FERM BP-5403)

An isolated endo-fucoidan-lyase is described. The enzyme acts on fucoidan, has a pH optimum from 6 to 10, and has an optimum pH from 30 to 40&deg; C. The enzyme can be isolated from Flavobacterium sp. FERM BP-5402. The enzyme is used to obtain sugar compounds which are useful in the study on carbohydrates.

Endo-fucoidan-lyase

2,3,4-trihydroxycyclopentanone

Oligosaccharides from enzymatic cleavage of fucoidan

Growing community of inventors

Hirosaki, Japan

Kaoru Kojima