Toa Eiyo Ltd.

Kaoru Gengyou

Kentaro Kogi

Shin-ichi Yamada

Atsuo Takahashi

Sen-ichi Narita

Hiroyasu Sato

Sachiko Ishigami

Toyoki Nishimata

Yoichi Manome

Takahiro Yamaguchi

Eiji Shimanuki

Isamu Sato

Tsuyoshi Aoki

A substituted cyclic amine compound represented by the following general formula (1) ##STR1## wherein each of R.sup.1 to R.sup.5 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or the like, A represents a carbonyl group or a sulfonyl group, B represents a methine moiety or a nitrogen atom, D represents a methine moiety, a nitrogen atom or .dbd.N(.fwdarw.O)-- and n is an integer of 2 to 3; and synthetic methods thereof. The inventive compound is useful in preventing and treating circulatory organ-related diseases such as hypertension, ischemic heart disease, cerebrovascular disease, peripheral circulatory disease and the like.

Substituted cyclic amine compound, production process thereof and

Growing community of inventors

Fukushima, Japan

Kaoru Gengyou