Kyowa Hakko Kirin Co., Limited

Kyowa Kirin Co., Ltd.

Kaori Yagi

Takeshi Kuboyama

Shintaro Hosoe

Tomoyuki Naoi

Kentaro Hatanaka

Tomohiro Era

Nobuhiro Yagi

The present invention provides nucleic acid-containing lipid nanoparticles containing a lipid (lipid A) which has a hydrophilic unit having a single quaternary ammonium group, and three independent, optionally substituted hydrocarbon groups, a lipid derivative or fatty acid derivative of a water-soluble polymer, and a nucleic acid.

Nucleic acid-containing lipid nanoparticles

Provided are a cationic lipid which facilitates the introduction of a nucleic acid into, for example, a cell or the like; a composition containing the cationic lipid and a nucleic acid; a method for introducing a nucleic acid into a cell by using a composition containing the cationic lipid and the nucleic acid; and the like. The cationic lipid is, for example, a cationic lipid represented by formula (A): formula (A): (wherein Ris alkenyl or the like, Ris alkenyl or the like, Rand Rare each alkyl, or are combined together to form alkylene, or Rand Rare combined together to form alkylene, Ris a hydrogen atom or the like, or is combined together with Rto form alkylene, Xis alkylene, and Xis a single bond or alkylene).

Cationic lipid

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Tokyo, Japan

Kaori Yagi