Daiichi Sankyo Company, Limited

Sanford Burnham Prebys Medical Discovery Institute

Kaori Soma

Anthony B Pinkerton

Yuko Yamamoto

Shojiro Miyazaki

Masanori Izumi

Masaharu Inui

Keisuke Suzuki

Taeko Shinozaki

Masamichi Kishida

Yasunobu Kurosaki

The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I) or a pharmacologically acceptable salt thereof. 

Sulfonamide compounds

The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I): wherein Rrepresents a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, Rand Rare the same or different and each represent a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, Rand Rare the same or different and each represent a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, Rrepresents a hydrogen atom or the like, each Rmay be the same or different and may each represent an optionally substituted C1-6 alkoxy group or the like, X represents &#x2014;CH&#x2550;, &#x2014;C(&#x2014;R)&#x2550;, or &#x2014;N&#x2550;, and m represents 1 to 4, or a pharmacologically acceptable salt thereof.

Pyridine compounds

The present invention relates to a compound or a pharmacologically acceptable salt thereof having excellent tissue non-specific alkaline phosphatase inhibitory activity. The present invention provides a compound represented by the formula (I): wherein Rrepresents a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, Rand Rare the same or different and each represent a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, R4 and R5 are the same or different and each represent a hydrogen atom, an optionally substituted C1-6 alkyl group, or the like, Rrepresents a hydrogen atom or the like, each Rmay be the same or different and may each represent an optionally substituted C1-6 alkoxy group or the like, X represents &#x2014;CH&#x2550;, &#x2014;C(&#x2014;R)&#x2550;, or &#x2014;N&#x2550;, and m represents 1 to 4, or a pharmacologically acceptable salt thereof. 

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Shinagawa-ku, Japan

Kaori Soma