Daiichi Sankyo Company, Limited

Sankyo Company, Limited

Kaori Nakahara

Jun Hasegawa

Takeshi Takizawa

Toshinori Agatsuma

Toshiaki Ohtsuka

Atsushi Urano

Junko Yamaguchi

Yasuteru Iijima

Kazuishi Kubota

Ayako Hara

Yohei Ozeki

The present invention provides an antibody which recognizes an epitope recognized by an antibody produced by a hybridoma SH348-1 (FERM BP-10836) or a hybridoma SH357-1 (FERM BP-10837), an antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, an antibody obtained by humanizing the antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, a pharmaceutical agent comprising the antibody as an active ingredient, etc.

Anti-EPHA2 antibody

Problem to Be Solved It is intended to provide an antibody having an inhibitory activity against cell malignant transformation and/or tumor cell growth, etc. Solution The present invention provides an antibody which recognizes an epitope recognized by an antibody produced by a hybridoma SH348-1 (FERM BP-10836) or a hybridoma SH357-1 (FERM BP-10837), an antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, an antibody obtained by humanizing the antibody produced by the hybridoma SH348-1 or the hybridoma SH357-1, a pharmaceutical agent comprising the antibody as an active ingredient, etc.

Polypeptides having 2',5&#x2032;-oligoadenylate phosphodiesterase activity, antibodies against the polypeptides, polynucleotides coding for the polypeptides, recombinant plasmid DNAs into which the polynucleotides have been inserted, host cells transformed by the recombinant plasmid DNAs, processes for screening for 2&#x2032;,5&#x2032;-oligoadenylate phosphodiesterase activity inhibitor substances, and processes for screening for 2&#x2032;,5&#x2032;-oligoadenylate phosphodiesterase expression regulation inhibitor substances. The polypeptides, polynucleotides and host cells are useful for searching for therapeutic agents for viral infections and tumors.

2', 5&#x2032;-oligoadenylate phosphodiesterase

Growing community of inventors

Tokyo, Japan

Kaori Nakahara